目的 探討小兒肺咳顆粒聯(lián)合哌拉西林鈉他唑巴坦鈉治療嬰幼兒支氣管肺炎的臨床療效。方法 選取2021年3月—2023年2月滄州市人民醫(yī)院收治的120例嬰幼兒支氣管肺炎患兒，按隨機(jī)數(shù)字表法將患者分對照組（60例）和治療組（60例）。對照組患兒靜脈滴注注射用哌拉西林鈉他唑巴坦鈉，3.375 g/次加入生理鹽水100 mL，1次/d。在對照組的基礎(chǔ)上，治療組口服小兒肺咳顆粒，1袋/次，3次/d。兩組用藥7 d觀察療效。觀察兩組患兒臨床療效，比較治療前后兩組患兒癥狀改善時間，白細(xì)胞（WBC）和中性粒細(xì)胞（NE）水平，及血清腫瘤壞死因子-α（TNF-α）、降鈣素原（PCT）、乳酸脫氫酶（LDH）、C反應(yīng)蛋白（CRP）水平，及不良反應(yīng)情況。結(jié)果 治療后，治療組總有效率（98.33%）明顯高于對照組（83.33%，P＜0.05）。治療后，治療組肺部啰音、發(fā)熱、氣促、咳嗽改善時間均明顯短于對照組（P＜0.05）。治療后，兩組患兒WBC、NE、LDH、PCT、TNF-α、CRP水平均明顯低于治療前（P＜0.05），且治療組這些指標(biāo)明顯低于對照組（P＜0.05）。治療后，治療組不良反應(yīng)發(fā)生率為5.01%，明顯低于對照組（13.33%，P＜0.05）。結(jié)論 小兒肺咳顆粒聯(lián)合哌拉西林鈉他唑巴坦鈉治療嬰幼兒支氣管肺炎，可有效改善肺炎咳嗽、發(fā)熱等癥狀，顯著恢復(fù)肝功能，明顯減弱肺部炎性反應(yīng)。

Objective To explore the clinical effect of Xiao’er Feike Granules combined with piperacillin sodium and tazobactam sodium in treatment of infantile bronchopneumonia. Methods Children (120 cases) with bronchopneumonia in Cangzhou People’s Hospital from March 2021 to February 2023 were were divided into control group (60 cases) and treatment group (60 cases) according to random number table method. Children in the control group were iv administered with Piperacillin Sodium and Tazobactam Sodium for injection, 3.375 g/time added into normal saline 100 mL, once daily. Children in the treatment group were po administered with Xiao’er Feike Granules on the basis of the control group, 1 bag/time, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical evaluations were evaluated, the symptom relief time, the levels of WBC, NE, CRP, PCT, LDH and TNF-α, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (98.33%) was significantly higher than that of the control group (83.33%, P < 0.05). After treatment, the improvement time of lung rales, fever, shortness of breath and cough in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the levels of WBC, NE, LDH, PCT, TNF-α and CRP in two groups were significantly lower than those before treatment (P < 0.05), and these indexes in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the incidence of adverse reactions (5.01%) in the treatment group was significantly lower than that in the control group (13.33%, P<0.05). Conclusion Xiao’er Feike Granules combined with piperacillin sodium and tazobactam sodium in treatment of infantile bronchopneumonia is effective in improving symptoms such as pneumonia, cough, fever and other symptoms, which also can significantly restore liver function, and weaken pulmonary inflammatory reaction.

R974

河北省醫(yī)學(xué)科學(xué)研究課題計(jì)劃（20232096）