目的 探討龍七胃康片聯(lián)合艾司奧美拉唑腸溶膠囊治療胃潰瘍的臨床效果。方法 選取2022年1月—2023年6月在鄭州市第七人民醫(yī)院接受治療的胃潰瘍患者94例，隨機分為對照組（47例）和治療組（47例）。對照組患者口服艾司奧美拉唑腸溶膠囊，20 mg/次，2次/d。治療組患者在對照組的治療基礎上口服龍七胃康片，3片/次，3次/d。兩組均治療4周。觀察兩組的臨床療效、潰瘍愈合情況、臨床癥狀消失時間、胃泌素、C反應蛋白（CRP）、白細胞介素-17（IL-17）的水平。結(jié)果 治療后，治療組的總有效率為95.74%，顯著高于對照組的80.85%（P＜0.05）。治療后，治療組潰瘍愈合率為87.23%，顯著高于對照組的70.21%（P＜0.05）。治療組腹痛、反酸、噯氣消失時間均顯著短于對照組（P＜0.05）。治療后，兩組胃泌素、CRP、IL-17水平均較同組治療前顯著明降低（P＜0.05）；且治療后，治療組患者的胃泌素、CRP、IL-17水平低于對照組（P＜0.05）。結(jié)論 龍七胃康片聯(lián)合艾司奧美拉唑腸溶膠囊治療胃潰瘍具有較好的臨床療效，可有效促進潰瘍愈合、縮短臨床癥狀消失時間，改善機體的胃腸激素及炎癥指標水平，且無明顯的藥物不良反應。

Objective To explore the therapeutic effect of Longqi Weikang Tablets combined with esomeprazole in treatment of gastric ulcers. Methods A total of 94 patients with gastric ulcer who received treatment in Zhengzhou Seventh People’s Hospital from January 2022 to June 2023 were randomly divided into control group (47 cases) and treatment group (47 cases). Patients in the control group were po administered with Esomeprazole Enteric Capsules, 20 mg/time, twice daily. Patients in the treatment group were po administered with Longqi Weikang Tablets on the basis of the control group, 3 tablets/time, three times daily. Patients in two groups were treated for 4 weeks. The clinical efficacy, ulcer healing, duration of clinical symptoms and the levels of gastrin, C-reactive protein (CRP) and interleukin-17 (IL-17) in two groups were observed. Results After treatment, the total effective rate of treatment group was 95.74%, which was significantly higher than that of control group (80.85%, P< 0.05). After treatment, the ulcer healing rate in treatment group was 87.23%, which was significantly higher than that in control group (70.21%) (P< 0.05). The disappearance time of abdominal pain, acid reflux and belching in treatment group was significantly shorter than that in control group (P< 0.05). After treatment, the levels of gastrin, CRP, and IL-17 in two groups were significantly decreased compared with before treatment (P < 0.05). After treatment, the levels of gastrin, CRP, and IL-17 in treatment group were lower than those in control group (P < 0.05). Conclusion Longqi Weikang Tablets combined with esomeprazole has good clinical efficacy in treatment of gastric ulcers, and can effectively promote ulcer healing, shorten the time for clinical symptom disappearance, improve the levels of gastrointestinal hormones and inflammatory indicators in the body, which has no obvious adverse drug reactions.

R975

河南省醫(yī)學科技攻關省部共建青年項目（SBGJ202103106）