目的 探討桑枝總生物堿片聯(lián)合德谷門冬雙胰島素注射液治療2型糖尿病的臨床療效。方法 納入2021年1月—2022年12月興安盟人民醫(yī)院108例2型糖尿病患者，以隨機數(shù)表法分為對照組和治療組，每組54例。對照組患者皮下注射德谷門冬雙胰島素注射液，1次/d，隨每日最大一餐給藥。治療組患者在對照組基礎(chǔ)上口服桑枝總生物堿片，1片/次，3次/d，嚼碎后與第一口或前幾口食物一起服用。兩組均連續(xù)治療4周。比較兩組的臨床療效、血糖指標、血糖波動指標和胰島素功能指標。結(jié)果 治療后，治療組和對照組總有效率分別為94.44%、81.48%，組間比較差異有統(tǒng)計學意義（P＜0.05）。治療后，兩組空腹血糖（FPG）、餐后2 h血糖（2 h PG）、糖化血紅蛋白（HbAlc）、血糖水平標準差（SDBG）、日間血糖平均絕對差（MODD）、平均血糖波動幅度（MAGE）均較治療前降低（P＜0.05），且治療組FPG、2 h PG、HbAlc、SDBG、MODD、MAGE更低（P＜0.05）。治療后，兩組空腹胰島素（FINS）、胰島β細胞功能指數(shù)（HOMA-β）均顯著升高，胰島素抵抗指數(shù)（HOMA-IR）均顯著降低（P＜0.05），且治療組患者FINS、HOMA-β均顯著高于對照組，HOMA-IR低于對照組（P＜0.05）。結(jié)論 桑枝總生物堿片聯(lián)合德谷門冬雙胰島素注射液素治療2型糖尿病的臨床療效確切，可顯著降低患者血糖，減少血糖波動，改善胰島β細胞功能和胰島素抵抗。

Objective To explore clinical effect of Mulberry Twig Alkaloids Tablets combined with Insulin Degludec and Insulin Aspart Injection in treatment of type 2 diabetes mellitus. Methods Patients (108 cases) with type 2 diabetes mellitus in Xing’an League People’s Hospital from January 2021 to December 2022 were divided into control and treatment groups according to the random number table method, and each group had 54 cases. Patients in the control group were sc injected with Insulin Degludec and Insulin Aspart Injection, once daily, taking the medicine with the largest meal of the day. Patients in the treatment group were po administered with Mulberry Twig Alkaloids Tablets on the basis of the control group, 1 tablets/time, three times daily, after chewing, taking it together with the first bite or first few bites of food. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies, blood glucose index, blood glucose fluctuation index, and insulin function index in two groups were compared. Results After treatment, the total effective rate of treatment group and control group was 94.44% and 81.48%, respectively, and the difference between groups was statistically significant (P < 0.05). After treatment, FPG, 2 h PG, HbAlc, SDBG, MODD, and MAGE in two groups were lower than those before treatment (P < 0.05), and FPG, 2 h PG, HbAlc, SDBG, MODD, and MAGE in treatment group were lower than those in the control group (P < 0.05). After treatment, FINS and HOMA-β in two groups were significantly increased, but HOMA-IR in two groups was significantly decreased (P < 0.05), and FINS and HOMA-β in the treatment group were significantly higher than those in the control group, while HOMA-IR in the treatment group was lower than that in the control group (P< 0.05). Conclusion Mulberry Twig Alkaloids Tablets combined with Insulin Degludec and Insulin Aspart Injection has a definite clinical effect in treatment of type 2 diabetes mellitus, can significantly reduce blood sugar in patients, reduce blood sugar fluctuations, improve islet β cell function and insulin resistance.

R977

內(nèi)蒙古自治區(qū)科技計劃項目（2020GG0253）