目的 觀察保胎靈膠囊聯(lián)合醋酸阿托西班注射液治療晚期先兆流產(chǎn)的臨床效果。方法 選取邯鄲市婦幼保健院2020年3月—2021年12月100例晚期先兆流產(chǎn)患者進(jìn)行研究，按隨機(jī)抽簽法分為對(duì)照組和治療組，各50例。對(duì)照組給予醋酸阿托西班注射液，首次靜脈注射6.75 mg（時(shí)間＞1 min，0.9 mL/6.75 mg），繼以5 mL/37.5 mg（共20 mL）溶于180 mL葡萄糖中靜滴（24 mL/h，持續(xù)3 h），3 h后以8 mL/h靜滴，直至達(dá)到宮縮抑制效果。治療組在對(duì)照組基礎(chǔ)上口服保胎靈膠囊，3粒/次，3次/d，持續(xù)2周。比較兩組的臨床療效、癥狀改善時(shí)間、血清性激素水平和母嬰結(jié)局。結(jié)果 治療后，治療組總有效率較對(duì)照組高（P＜0.05）。治療組腰酸改善時(shí)間、腹痛改善時(shí)間和陰道出血停止時(shí)間較對(duì)照組短（P＜0.05）。治療后，兩組血清人絨毛膜促性腺激素（hCG）、孕酮（P）、雌二醇（E₂）水平均較治療前升高（P＜0.05），且治療組血清性激素水平較對(duì)照組高（P＜0.05）。治療后，治療組足月分娩例數(shù)高于對(duì)照組，自然流產(chǎn)例數(shù)低于對(duì)照組（P＜0.05）。結(jié)論 保胎靈膠囊聯(lián)合醋酸阿托西班注射液治療晚期先兆流產(chǎn)療效確切，可改善患者臨床癥狀，調(diào)節(jié)血清性激素水平，改善母嬰結(jié)局。

Objective To observe the clinical effect of Baotailing Capsules combined with Atosiban Acetate Injection in treatment of advanced threatened abortion. Methods Women (100 cases) with advanced threatened abortion in Handan Maternal and Child Health Hospital from March 2020 to December 2021 were divided into control and treatment groups according to the random drawing method, and each group had 50 cases. Women in the control group were iv administered with Atosiban Acetate Injection, the first infusion was 6.75 mg (time > 1 min, 0.9 mL/6.75 mg), followed by 5 mL/37.5 mg (total 20 mL) dissolved in 180 mL glucose by intravenous drip (24 mL/h for 3 h), and 3 h later by intravenous drip at 8 mL/h until the contraction inhibition effect was achieved. Women in the treatment group were po administered with Baotailing Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies, symptom improvement time, serum sex hormone levels, and maternal and infant outcomes in two groups were compared. Results After treatment, the total effective rate of the treatment group was higher than that of the control group (P < 0.05). The improvement time of lumbar acid, abdominal pain and vaginal bleeding in the treatment group were shorter than those in the control group (P < 0.05). After treatment, the serum levels of hCG, P, and E₂ in two groups were higher than before treatment (P< 0.05), and the serum sex hormone levels in the treatment group were higher than those in the control group (P < 0.05). After treatment, the number of full-term eliveries in the treatment group was higher than that in the control group, but the number of natural abortions was lower than that in the control group (P < 0.05). Conclusion Baotailing Capsules combined with Atosiban Acetate Injection is effective in treatment of advanced threatened abortion, can improve clinical symptoms, adjust sex hormone levels, improve maternal and infant outcomes.

R984

河北省醫(yī)學(xué)科學(xué)研究課題計(jì)劃（20231932）