目的 探討紅金消結(jié)膠囊聯(lián)合左炔諾孕酮宮內(nèi)緩釋系統(tǒng)治療子宮肌瘤的臨床療效。方法 選取鄭州市第七人民醫(yī)院2021年7月至2023年1月收治的96例子宮肌瘤患者作為研究對(duì)象，按隨機(jī)抽簽法分為對(duì)照組和治療組，各48例。對(duì)照組采用左炔諾孕酮宮內(nèi)釋放系統(tǒng)，于月經(jīng)后3～5 d刮除大部分內(nèi)膜后放置左炔諾孕酮宮內(nèi)節(jié)育系統(tǒng)，療程為3個(gè)月。治療組在對(duì)照組基礎(chǔ)上口服紅金消結(jié)膠囊，4粒/次，3次/d。兩組連續(xù)治療3個(gè)月。比較兩組的臨床療效、月經(jīng)出血量、子宮體積、肌瘤體積、生活質(zhì)量、血清性激素水平。結(jié)果 治療后，治療組的總有效率較對(duì)照組高（P＜0.05）。治療后，兩組月經(jīng)出血量、子宮體積、肌瘤體積以及血清促黃體生成素（LH）、卵泡刺激素（FSH）、孕酮（P）、雌二醇（E₂）水平均低于治療前，物質(zhì)生活狀態(tài)評(píng)分、軀體功能評(píng)分、心理功能評(píng)分、社會(huì)功能評(píng)分均高于治療前（P＜0.05），且治療組相關(guān)指標(biāo)優(yōu)于對(duì)照組（P＜0.05）。結(jié)論 紅金消結(jié)膠囊聯(lián)合左炔諾孕酮宮內(nèi)緩釋系統(tǒng)治療子宮肌瘤可縮小子宮和肌瘤體積，降低月經(jīng)出血量，提高生活質(zhì)量，改善性激素水平。

Objective To investigate the clinical efficacy of Hongjin Xiaojie Capsules combined with Levonorgestrel-Releasing Intrauterine System in treatment of uterine fibroids. Methods Women (96 cases) with uterine fibroids in the 7th People’s Hospital of Zhengzhou from July 2021 to January 2023 were divided into control and treatment groups according to the random drawing method, and each group had 48 cases. Women in the control group received Levonorgestrel-Releasing Intrauterine System, and placed Levonorgestrel-Releasing Intrauterine System 3 - 5 d after menstruation, after shaving most of the endometrial, and the course of treatment was 3 months. Women in the treatment group were po administered with Hongjin Xiaojie Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies, menstrual blood loss, uterine volume, fibroid volume, quality of life, and serum sex hormone level in two groups were compared. Results After treatment, the total effective rate of the treatment group was higher than that of the control group (P < 0.05). After treatment, the amount of menstrual bleeding, uterine volume, and fibroid volume, and the serum levels of LH, FSH, P, and E₂in the two groups were lower than before treatment, the material living status score, physical function score, psychological function score, and social function score of two groups were higher than before treatment (P < 0.05), and the above indexes in the treatment group were better than those in the control group (P < 0.05). Conclusion Hongjin Xiaojie Capsules combined with Levonorgestrel- Releasing Intrauterine System in treatment of uterine fibroids can reduce the volume of uterus and fibroids, reduce menstrual bleeding, improve quality of life, and improve sex hormone levels.

R984

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃（聯(lián)合共建）項(xiàng)目（LHGJ20191322）