目的 探討銀花泌炎靈片聯(lián)合諾氟沙星膠囊治療Ⅲ型前列腺炎的臨床效果。方法 選取2021年1月—2022年12月上海市浦東新區(qū)浦南醫(yī)院收治的83例Ⅲ型前列腺炎患者作為研究對象，采用隨機數(shù)字表法將患者分為對照組（41例）和治療組（42例）。對照組口服諾氟沙星膠囊，0.4 g/次，2次/d。治療組在對照組基礎(chǔ)上口服銀花泌炎靈片，4片/次，4次/d。兩組連續(xù)治療8周。比較兩組的臨床療效、病情程度、尿流動力學(xué)指標(biāo)和血清炎癥因子。結(jié)果 治療后，治療組的總有效率（97.62%）明顯高于對照組（80.49%），差異有統(tǒng)計學(xué)意義（P＜0.05）。治療后，兩組美國國立衛(wèi)生研究院慢性前列腺炎癥狀（NIH-CPSI）評分較治療前明顯降低（P＜0.05），且治療組NIH-CPSI評分低于對照組（P＜0.05）。治療后，兩組患者最大尿流率均升高，殘余尿量均下降（P＜0.05），且治療組最大尿流率高于對照組，殘余尿量組低于對照組（P＜0.05）。治療后，兩組血清白細胞介素-8（IL-8）、白細胞介素-10（IL-10）、腫瘤壞死因子-α（TNF-α）水平較治療前下降（P＜0.05），且治療組血清IL-8、IL-10、TNF-α水平較對照組更低（P＜0.05）。結(jié)論 銀花泌炎靈片聯(lián)合諾氟沙星膠囊對Ⅲ型前列腺炎的臨床療效良好，可有效緩解病情，改善尿流動力學(xué)，降低炎癥反應(yīng)程度。

Objective To investigate the clinical effect of Yinhua Miyanling Tablets combined with Norfloxacin Capsules in treatment of type Ⅲ prostatitis. Methods Patients (83 cases) with type Ⅲ prostatitis in Shanghai Punan Hospital of Pudong New Area from January 2021 to December 2022 were divided into the control group (41 cases) and the treatment group (42 cases) according to random number tablet method. Patients in the control group were po administered with Norfloxacin Capsules, 0.4 g/time, twice daily. Patients in the treatment group were po administered with Yinhua Miyanling Tablets on the basis of the control group, 4 tablets/time, four times daily. Patients in two groups were treated for 8 weeks. The clinical efficacy, condition, urodynamic indexes, and serum inflammatory factors in two groups were compared. Results After treatment, the total effective rate of the treatment group (97.62%) was significantly higher than 80.49% of the control group, and the difference was statistically significant (P < 0.05). After treatment, NIH-CPSI score of two groups was significantly lower than that before treatment (P < 0.05), and NIH-CPSI score of the treatment group was significantly lower than that of the control group (P < 0.05). After treatment, the maximum urine flow rate increased in two groups, but the residual urine volume in two groups decreased (P < 0.05). And the maximum urine flow rate in the treatment group was higher than that in the control group, but the residual urine volume in the treatment group was lower than that in the control group (P < 0.05). After treatment, the serum levels of IL-8, IL-10, and TNF-α in two groups were significantly decreased compared with that before treatment (P < 0.05), and the serum levels of IL-8, IL-10, and TNF-α in the treatment group were lower than those in the control group (P < 0.05). Conclusion Yinhua Miyanling Tablets combined with Norfloxacin Capsules has good efficacy in treatment of type Ⅲ prostatitis, which can effectively alleviate the condition, improve urodynamics, and reduce the degree of inflammatory response.

R983

上海市浦東新區(qū)衛(wèi)生健康委員會學(xué)科建設(shè)計劃項目（PWZzb2022-07）