目的 探討石榴補(bǔ)血糖漿聯(lián)合蔗糖鐵治療術(shù)后缺鐵性貧血的臨床療效。方法 選取2021年3月—2023年3月上海中醫(yī)藥大學(xué)附屬曙光醫(yī)院收治的96例術(shù)后缺鐵性貧血患者，按照隨機(jī)數(shù)字表法分對(duì)照組和治療組，每組各48例。對(duì)照組患者靜脈滴注蔗糖鐵注射液，0.9%氯化鈉注射液100 mL加入蔗糖鐵注射液100 mg，3次/周。治療組在對(duì)照組治療基礎(chǔ)上口服石榴補(bǔ)血糖漿，20 mL/次，3次/d。兩組用藥30 d。觀察兩組的臨床療效和癥狀緩解時(shí)間，比較兩組治療前后血常規(guī)指標(biāo)和血清炎性因子的變化情況。結(jié)果 治療后，治療組總有效率是97.92%，顯著高于對(duì)照組的81.25%（P＜0.05）。治療后，治療組乏力、心悸、頭暈、皮膚黏膜蒼白改善時(shí)間均顯著短于對(duì)照組（P＜0.05）。治療后，兩組患者血紅蛋白（HGB）、血清鐵蛋白（SF）、轉(zhuǎn)鐵蛋白飽和度（TS）、血細(xì)胞比容（HCT）水平均較同組治療前顯著升高（P＜0.05）；治療后，治療組的HGB、SF、TS、HCT水平均高于對(duì)照組（P＜0.05）。治療后，兩組患者血清白細(xì)胞介素-6（IL-6）、膜結(jié)合絲氨酸蛋白酶-2（MTPS-2）、血清鐵調(diào)素（Hepcidin）、腫瘤壞死因子-α（TNF-α）水平均較同組治療前顯著降低（P＜0.05）；治療后，治療組IL-6、MTPS-2、Hepcidin、TNF-α水平均顯著低于對(duì)照組（P＜0.05）。結(jié)論 石榴補(bǔ)血糖漿聯(lián)合蔗糖鐵治療術(shù)后缺鐵性貧血有較好的臨床療效，可明顯改善患者貧血狀態(tài)，提高機(jī)體內(nèi)鐵水平，減弱術(shù)后炎性反應(yīng)，值得借鑒應(yīng)用。

Objective To explore the clinical efficacy of Shiliu Buxue Syrup combined with iron sucrose in treatment of postoperative iron deficiency anemia. Methods Ninety-six patients with postoperative iron deficiency anemia admitted to Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from March 2021 to March 2023 were selected and divided into control group and treatment group according to random number table method, with 48 cases in each group. Patients in the control group were iv administered with Iron Sucrose Injection, 0.9% sodium chloride injection 100 mL added Iron Sucrose Injection 100 mg, 3 times weekly. Patients in the treatment group were po administered with Shiliu Buxue Syrup on the basis of the control group, 20 mL/time, 3 times daily. Both groups were treated for 30 d. The clinical efficacy and symptom remission time of the two groups were observed, and the changes of blood routine indexes and serum inflammatory factors before and after treatment were compared. Results After treatment, the total effective rate of treatment group was 97.92%, which was significantly higher than that of control group (81.25%, P < 0.05). After treatment, the improvement time of fatigue, palpitation, dizziness, and pale skin mucosa in treatment group was significantly shorter than that in control group (P < 0.05). After treatment, the levels of hemoglobin (HGB), serum ferritin (SF), transferrin saturation (TS), and hematocrit (HCT) in 2 groups were significantly increased compared with before treatment (P < 0.05). After treatment, the HGB, SF, TS, and HCT levels in the treatment group were higher than those in control group (P < 0.05). After treatment, the levels of interleukin-6 (IL-6), membrane-bound serine proteinase-2 (MTPS-2), serum ferritin (Hepcidin), and tumor necrosis factor-α (TNF-α) in 2 groups were significantly decreased compared with those before treatment (P < 0.05). After treatment, the levels of IL-6, MTPS-2, Hepcidin, and TNF-α in the treatment group were significantly lower than those in control group (P < 0.05). Conclusion Shiliu Buxue Syrup combined with iron sucrose has good clinical effect in treatment of postoperative iron deficiency anemia, and can obviously improve the anemia state of patients, increase the iron level in the body, which can weaken the postoperative inflammatory response.

R973