目的 探討小兒定喘口服液聯(lián)合硫酸沙丁胺醇治療小兒輕中度支氣管哮喘的臨床療效。方法 選取2022年7月—2023年7月河南省兒童醫(yī)院收治的輕中度支氣管哮喘患兒90例，隨機(jī)分為對(duì)照組（45例）和治療組（45例）。對(duì)照組患者霧化吸入硫酸沙丁胺醇吸入氣霧劑，100 µg/次，1次/6 h。治療組在對(duì)照組的基礎(chǔ)上口服小兒定喘口服液，10 mL/次，3次/d。兩組連服藥7 d。觀察兩組患者臨床療效，比較治療前后兩組患者癥狀改善時(shí)間，血清超氧化物歧化酶（SOD）、內(nèi)皮素（ET）、一氧化氮（NO）、白細(xì)胞介素-6（IL-6）、干擾素-γ（INF-γ）、降鈣素原（PCT）和血白三烯C4（LTC4）水平，及不良反應(yīng)情況。結(jié)果 治療后，治療組患者臨床總有效率為97.78%，明顯高于對(duì)照組（82.22%，P＜0.05）。治療后，治療組癥狀改善時(shí)間明顯早于對(duì)照組（P＜0.05）。治療后，兩組SOD和INF-γ水平明顯升高，而ET、NO、IL-6、PCT、LTC4水平明顯降低（P＜0.05），且治療組這些指標(biāo)水平明顯好于對(duì)照組（P＜0.05）。治療組不良反應(yīng)發(fā)生率（6.67%）明顯低于對(duì)照組（20.00%）（P＜0.05）。結(jié)論 硫酸沙丁胺醇聯(lián)合小兒定喘口服液治療小兒輕中度支氣管哮喘，可有效改善氧化應(yīng)激反應(yīng)，并減弱支氣管炎性反應(yīng)。

Objective To explore the clinical effect of Xiao'er Dingchuan Oral Liquid combined with salbutamol sulfate in treatment of mild to moderate bronchial asthma in children. Methods Children (90 cases) with mild to moderate bronchial asthma in Henan Children's Hospital from July 2022 to July 2023 were randomly divided into control (45 cases) and treatment (45 cases) group. Children in the control group were administered with Salbutamol Sulfate Inhalation Aerosol, 100 µg/time, once every 6 h. Children in the treatment group were po administered with Xiao'er Dingchuan Oral Liquid on the basis of the control group, 10 mL/time, three time daily. Children in two groups were treated for 7 d. After treatment, the clinical evaluations were evaluated, the symptom relief time, the levels of serum SOD, ET, NO, IL-6, PCT, LTC4 and INF-γ, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 97.78%, which was significantly higher than that of the control group (82.22%, P < 0.05). After treatment, the time of symptom improvement in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the levels of SOD and INF-γ were significantly increased, while the levels of ET, NO, IL-6, PCT and LTC4 were significantly decreased in two groups (P < 0.05), and these indexes in the treatment group were significantly better than those in the control group (P < 0.05). The incidence of adverse reactions in the treatment group (6.67%) was significantly lower than that in the control group (19.78%) (P < 0.05). Conclusion Xiao'er Dingchuan Oral Liquid combined with salbutamol sulfate in treatment of mild to moderate bronchial asthma in children can effectively improve the oxidative stress response and reduce the bronchial inflammatory response.

R974

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃聯(lián)合共建項(xiàng)目（LHGJ20210647）