目的 分析小兒熱速清口服液聯(lián)合環(huán)酯紅霉素治療小兒急性上呼吸道感染的臨床療效。方法 選取2022年1月—12月北京市通州區(qū)婦幼保健院收治的急性上呼吸道感染患兒116例，按隨機(jī)數(shù)字表法將所有患者分為對(duì)照組和治療組，每組各58例。對(duì)照組患兒口服環(huán)酯紅霉素干混懸劑，15 mg/kg，每12 h給藥1次，將本品加入適量涼開水溶解搖勻后口服。治療組在對(duì)照組治療基礎(chǔ)上口服小兒熱速清口服液，1≤年齡≤3歲、3歲＜年齡≤6歲、6歲＜年齡≤12歲者分別給予10、15、20 mL/次，3次/d。兩組療程是5 d。觀察兩組臨床療效、完全退熱時(shí)間及其他癥狀消失時(shí)間。比較治療前后兩組兒童睡眠習(xí)慣問卷（CSHQ）、兒少主觀生活質(zhì)量問卷（ISLQ）評(píng)分及全血白細(xì)胞計(jì)數(shù)（WBC）、紅細(xì)胞沉降率（ESR）、C反應(yīng)蛋白（CRP）水平。結(jié)果 治療后，治療組總有效率是94.83%，與對(duì)照組的84.48%相比顯著更高（P＜0.05）。治療組完全退熱時(shí)間和鼻塞、流涕、扁桃體腫大、全身酸痛、咽痛、咳嗽的消失時(shí)間均顯著短于對(duì)照組（P＜0.05）。治療后，兩組CSHQ評(píng)分均顯著降低，而ISLQ評(píng)分均顯著增加（P＜0.05）；治療后，治療組CSHQ、ISLQ評(píng)分改善更顯著（P＜0.05）。治療后，兩組全血WBC、ESR、CRP水平均顯著下降（P＜0.05）；且治療組降低更顯著（P＜0.05）。結(jié)論 小兒熱速清口服液聯(lián)合環(huán)酯紅霉素治療小兒急性上呼吸道感染療效確切，能加速患兒癥狀和體征的改善，降低睡眠和生活質(zhì)量的受影響程度，值得臨床推廣應(yīng)用。

Objective To analyze the clinical efficacy of Xiaoer Resuqing Oral Liquid combined with erythromycin cyclocarbonate in treatment of acute upper respiratory tract infection in children. Methods A total of 116 children with acute upper respiratory tract infection treated in Tongzhou District Maternal and Child Health Hospital of Beijing from January to December 2022 were selected and divided into control group and treatment group according to random number table method, with 58 cases in each group. Children in the control group were po administered with Erythromycin Cyclocarbonate for Suspension, 15 mg/kg, once every 12 h, dissolved it in cold water, shaked well, and then took it orally. Children in the treatment group were po administered with Xiaoer Resuqing Oral Liquid, 1 ≤ age ≤ 3 years old, 3 years old < age ≤ 6 years old, 6 years old < age ≤ 12 years old were given 10, 15, 20 mL/time, 3 times daily, respectively. Both groups were treated for 5 d. The clinical effect, the time of complete fever remission and the time of other symptoms disappearance were observed. The scores of Sleep habits Questionnaire (CSHQ), Subjective Quality of Life Questionnaire (ISLQ), whole blood white blood cell count (WBC), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were compared between two groups before and after treatment. Results After treatment, the total effective rate of the treatment group was 94.83%, which was significantly higher than that of the control group (84.48%) (P < 0.05). The time of complete remission of fever and the disappearance time of nasal obstruction, runny nose, swollen tonsils, aching body, sore throat and cough in treatment group were significantly shorter than those in control group (P < 0.05). After treatment, CSHQ score was significantly decreased, but ISLQ score was significantly increased in both groups (P < 0.05). After treatment, CSHQ and ISLQ scores in treatment group were significantly improved (P < 0.05). After treatment, whole blood WBC,ESR and CRP levels were significantly decreased in both groups (P < 0.05). The decrease was more significant in treatment group (P < 0.05). Conclusion Xiaoer Resuqing Oral Liquid combined with erythromycin cyclocarbonate has definite curative effect in treatment of acute upper respiratory tract infection in children, and can accelerate the improvement of children's symptoms and signs, reduce the sleep degree and life quality affected, which is worthy of clinical application.

R974

北京市衛(wèi)生科技成果與適宜技術(shù)推廣項(xiàng)目資助基金（2018-TG-69）