目的 探討復方珍珠口瘡顆粒聯合康復新液治療口腔潰瘍的臨床療效。方法 選取2020年7月—2023年6月上海市嘉定區(qū)安亭醫(yī)院收治的96例口腔潰瘍患者，按隨機數字表法分為對照組和治療組，每組各48例。對照組含漱康復新液10 mL/次，每次含漱5 min，3次/d，用藥后30 min內避免漱口、禁飲禁食。治療組在對照組治療基礎上口服復方珍珠口瘡顆粒，1袋/次，2次/d，飯后30 min以100 mL開水溶解后分次口含，每次口含1～2 min后緩慢咽下，10 min內用完。兩組療程均為1周。觀察兩組的臨床療效、疼痛緩解和潰瘍面愈合時間。比較治療前后兩組疼痛視覺模擬量表（VAS）評分、14項口腔健康影響程度量表（OHIP-14）評分、癥狀自評量表（SCL-90）評分及血清白細胞介素-17（IL-17）、補體C3和C4、超氧化物歧化酶（SOD）和轉化生長因子-β（TGF-β）水平。結果 治療后，治療組總有效率是97.92%，較對照組的83.33%顯著提高（P＜0.05）。經治療，治療組疼痛緩解時間和潰瘍面愈合時間均顯著短于對照組（P＜0.05）。治療后，兩組疼痛VAS、OHIP-14和SCL-90評分均顯著降低（P＜0.05）；且治療后，治療組VAS、OHIP-14和SCL-90評分低于對照組（P＜0.05）。治療后，兩組血清IL-17水平均顯著降低，而血清補體C3、C4和SOD、TGF-β水平均顯著增高（P＜0.05）；且治療后，治療組血清IL-17、補體C3、補體C4、SOD和TGF-β水平改善優(yōu)于對照組（P＜0.05）。結論 復方珍珠口瘡顆粒聯合康復新液治療口腔潰瘍效果較好，能有效促進患者疼痛減輕和潰瘍面愈合，調節(jié)免疫紊亂及炎癥反應，對患者病情恢復、心理狀態(tài)及生活質量的改善效果明顯，值得臨床推廣應用。

Objective To investigate the clinical efficacy of Compound Zhenzhu Kouchuang Granules combined with Kangfuxin Liquid in treatment of oral ulcer. Methods A total of 96 patients with oral ulcer admitted to Anting Hospital of Jiading District in Shanghai from July 2020 to June 2023 were selected and divided into control group and treatment group according to random number table method, with 48 cases in each group. Patients in the control group were given Kangfuxin Liquid, 10 mL/time with gargling for 5 min each time, three times daily. Avoid gargling, drinking and fasting within 30 min after medication. Patients in the treatment group were given Compound Zhenzhu Kouchuang Granules on the basis of the control group, 1 bag/time, twice daily, dissolved in 100 mL boiling water 30 min after meal, swallowed slowly after 1-2 minutes each time, and used up within 10 min. The treatment course of both groups was 1 week. The efficacy, pain relief, and ulcer healing time were observed. The visual analogue scale (VAS) for pain, 14-item Oral Health Impact Profile (OHIP-14), Symptom Checklist-90 (SCL-90) scores, and serum interleukin-17 (IL-17), complement C3, C4, superoxide dismutase (SOD), and transforming growth factor-beta (TGF-β) levels were compared in two groups before and after treatment. Results After treatment, the total effective rate of the treatment group was 97.92%, which was significantly higher than that of control group (83.33%) (P < 0.05). After treatment, the pain relief time and ulcer healing time in treatment group were significantly shorter than those in control group (P < 0.05). After treatment, pain VAS, OHIP-14, and SCL-90 scores were significantly decreased in both groups (P < 0.05). After treatment, VAS, OHIP-14, and SCL-90 scores in the treatment group were lower than those in control group (P < 0.05). After treatment, serum IL-17 levels were significantly decreased in both groups, but serum complement C3, C4, SOD, TGF-β levels were significantly increased (P < 0.05). After treatment, the levels of IL-17, complement C3, complement C4, SOD and TGF-β in treatment group were better than those in control group (P < 0.05). Conclusion Compound Zhenzhu Kouchuang Granules combined with Kangfuxin Liquid has a good effect in treatment of oral ulcer, and can effectively promote patients' pain relief and ulcer surface healing, regulate immune disorders and inflammatory response, and improve patients' condition recovery, psychological state and life quality, which is worthy of clinical application.

R988.2