二苯并氮雜䓬類化合物是一種重要的含氮雜環(huán)類化合物。結(jié)構(gòu)修飾不僅可對二苯并氮雜䓬類化合物中心七元環(huán)環(huán)上氮原子進行改造，也可在兩邊的苯環(huán)上連接不同基團，不同取代基對其活性影響也不同。二苯并氮雜䓬類化合物具有心臟保護作用、血管性認知障礙保護作用、抗抑郁作用、抗焦慮作用、抗癲癇作用、降糖作用、抗癌作用、抗炎作用、抗氧化作用和鎮(zhèn)痛作用?？偨Y(jié)了二苯并氮雜䓬類化合物的藥理作用研究進展，以期為設(shè)計合成二苯并氮雜䓬類藥物及其潛在藥理活性提供參考。

Dibenzodiazepines are an important class of heterocyclic compounds. Structural modification of dibenzodiazepines can not only modify the nitrogen atom in the central seven-membered ring, but also connect other substituent groups to the benzene ring on both sides, and different substituents have different activities for it. Dibenzodiazepines have a wide range of pharmacological activities, including cardioprotective effects, vascular cognitive impairment protective effects, anti-depression, anti-anxiety effects, anti-epilepsy, hypoglycemic effects, anticancer effects, anti-inflammatory effects, antioxidant effects, and analgesic effects. This article summarizes the research progress on the pharmacological effects of dibenzoazepines, with the aim of providing reference for the design, synthesis, and potential pharmacological activities of dibenzoazepine drugs.

R914;R965

國家自然科學基金資助項目（82173710）；中國醫(yī)學科學院醫(yī)學與健康科技創(chuàng)新工程項目（2021-I2M-1-028,2022-I2M-2-002）；北京市自然科學基金資助項目（7192129）