范可尼貧血癥是一種罕見的人類遺傳疾病，常伴有癌癥易感性、骨髓衰竭和發(fā)育異常。范可尼貧血癥基因編碼的蛋白和相關(guān)蛋白構(gòu)成范可尼貧血癥通路。該通路參與DNA損傷修復(fù)，與腫瘤發(fā)生、腫瘤耐藥、化療藥物增敏等密切相關(guān)。歸納了范可尼貧血癥通路組成及其參與DNA損傷修復(fù)過程，討論了范可尼貧血癥通路的調(diào)控、對(duì)腫瘤耐藥、化療敏感性的影響，并總結(jié)了靶向范可尼貧血癥通路的小分子抑制劑，為癌癥干預(yù)提供新思路。

Fanconi anemia is a rare human genetic disease, often accompanied by susceptibility to cancer, bone marrow failure, and dysplasia. The proteins and related proteins encoded by the Fanconi anemia gene constitute the Fanconi anemia pathway. This pathway is involved in DNA damage repair and is closely related to tumor development, tumor resistance, and chemotherapy sensitization. This article summarizes the composition of the Fanconi anemia pathway and its involvement in DNA damage repair processes. It discusses the regulation of the Fanconi anemia pathway, and its impact on tumor drug resistance and chemotherapy sensitivity, and summarizes small molecule inhibitors targeting the Fanconi anemia pathway, which will provide new ideas for cancer intervention.

R973

北京市醫(yī)院管理局臨床醫(yī)學(xué)發(fā)展專項(xiàng)揚(yáng)帆計(jì)劃（ZYLX201827）