目的 探討偏癱復原丸聯(lián)合氯吡格雷治療急性腦梗死恢復期患者的治療效果。方法 選取2021年2月-2023年4月青海紅十字醫(yī)院收治的94例急性腦梗死患者,依據(jù)隨機數(shù)表法分為對照組(47例)和治療組(47例)。對照組患者口服硫酸氫氯吡格雷片,75 mg/次,1次/d。治療組患者在對照組治療基礎上口服偏癱復原丸,1丸/次,2次/d。兩組患者均連續(xù)治療4周。觀察兩組的臨床療效,比較兩組治療前后中醫(yī)癥狀積分及血清炎癥因子水平,比較兩組患者的短期預后情況和不良反應情況。結果 治療后,治療組的總有效率為93.62%,顯著高于對照組的78.72%(P<0.05)。治療后,兩組患者的頭暈目眩、肢體麻木、舌質(zhì)暗淡、氣短乏力評分較治療前明顯降低(P<0.05),且治療組中醫(yī)癥狀積分均低于對照組(P<0.05)。治療后,兩組患者的血清C反應蛋白(CRP)、單核細胞趨化蛋白-1(MCP-1)、白細胞介素-6(IL-6)水平較治療前明顯降低(P<0.05),且治療后,治療組血清CRP、MCP-1、IL-6水平改善情況更為明顯(P<0.05)。治療組的短期預后良好率為82.98%,顯著高于對照組的63.83%(P<0.05)。治療后,治療組不良反應發(fā)生率是6.38%,對照組是2.13%,兩組不良反應發(fā)生率比較差異無統(tǒng)計學意義。結論 偏癱復原丸聯(lián)合氯吡格雷對急性腦梗死恢復期患者具有較好的治療效果,可有效改善患者的中醫(yī)癥狀、炎癥狀態(tài)以及短期預后情況,不良反應發(fā)生率低,且癥狀輕微。

Objective To explore the therapeutic effect of Piantan Fuyuan Pills combined with clopidogrel in treatment of convalescent period of acute cerebral infarction. Methods 94 Patients with acute cerebral infarction admitted to Qinghai Red Cross Hospital from February 2021 to April 2023 were selected and divided into control group (47 cases) and treatment group (47 cases) according to random number table method. Patients in the control group were po administered with Clopidogrel Bisulfate Tablets, 75 mg/time, once daily. Patients in the treatment group were po administered with Piantan Fuyuan Pills on the basis of the control group, 1 pill/time, twice daily. Both groups were treated continuously for 4 weeks. The clinical efficacy of the two groups was observed, the TCM symptom score and serum inflammatory factor levels were compared before and after treatment, and the short-term prognosis and adverse reactions were compared between the two groups. Results After treatment, the total effective rate of the treatment group was 93.62%, which was significantly higher than that of the control group (78.72%, P < 0.05). After treatment, the scores of dizziness, numbness of limbs, dull tongue, and shortness of breath in both groups were significantly lower than before treatment (P < 0.05), and the scores of TCM symptoms in the treatment group were lower than those in the control group (P < 0.05). After treatment, the levels of serum C-reactive protein (CRP), monocyte chemoattractant protein-1 (MCP-1), and interleukin-6 (IL-6) in both groups were significantly decreased compared with those before treatment (P < 0.05), and after treatment, the levels of serum CRP, MCP-1, and IL-6 in the treatment group were significantly improved (P < 0.05). The good short-term prognosis rate in the treatment group was 82.98%, which was significantly higher than that in the control group (63.83%) (P < 0.05). After treatment, the incidence of adverse reactions was 6.38% in the treatment group and 2.13% in the control group. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion Piantan Fuyuan Pills combined with clopidogrel has a good therapeutic effect in treatment of convalescent period of acute cerebral infarction, and can effectively improve TCM symptoms, inflammatory state and short-term prognosis with low incidence of adverse reactions and mild symptoms.

R971

青海省衛(wèi)生健康系統(tǒng)指導性計劃課題（2022-wjzdx-95）