目的 觀察清咳平喘顆粒聯(lián)合復(fù)方甲氧那明治療感染后咳嗽(痰熱壅肺證)的臨床療效。方法 選取2023年4月-2023年6月在北京中醫(yī)藥大學(xué)第三附屬醫(yī)院、北京中醫(yī)醫(yī)院順義醫(yī)院、中國(guó)人民解放軍空軍特色醫(yī)學(xué)中心、首都醫(yī)科大學(xué)附屬北京中醫(yī)醫(yī)院、中國(guó)人民解放軍總醫(yī)院第四醫(yī)學(xué)中心、中國(guó)人民解放軍總醫(yī)院第七醫(yī)學(xué)中心和中國(guó)人民解放軍總醫(yī)院第八醫(yī)學(xué)中心7家醫(yī)院就診的178例感染后咳嗽(痰熱壅肺證)患者,隨機(jī)分為對(duì)照組(88例)和治療組(90例)。對(duì)照組口服復(fù)方甲氧那明膠囊,2粒/次,3次/d。治療組在對(duì)照組基礎(chǔ)上口服清咳平喘顆粒,1袋/次,3次/d。兩組均治療7 d。觀察兩組患者臨床療效,比較治療前后兩組患者咳嗽程度評(píng)分,咳嗽緩解和消失時(shí)間,及炎癥指標(biāo)白細(xì)胞計(jì)數(shù)(WBC)、C反應(yīng)蛋白(CRP)和白介素-6(IL-6)水平。結(jié)果 治療后,治療組總有效率為97.73%,顯著高于對(duì)照組(89.77%,P<0.05)。治療后,兩組患者咳嗽程度顯著改善(P<0.05),其中治療組咳嗽程度評(píng)分在第7天的改善程度顯著強(qiáng)于對(duì)照組(P<0.05)。治療后,治療組咳嗽癥狀的緩解時(shí)間和消失時(shí)間均顯著短于對(duì)照組(P<0.05)。治療后,兩組患者WBC、IL-6、CRP的水平均顯著降低(P<0.05),且治療組IL-6和CRP的水平下降顯著(P<0.05)。結(jié)論 清咳平喘顆粒聯(lián)合復(fù)方甲氧那明能夠顯著提高臨床有效率,改善患者咳嗽程度,促進(jìn)咳嗽癥狀的緩解與消失,降低炎癥水平。

Objective Observe the clinical efficacy of Qingke Pingchuan Granules combined with compound methoxyphenamine in treatment of postinfectious cough (phlegm heat obstruction of the lung syndrome). Methods A total of 178 patients with postinfectious cough (phlegm heat obstruction of the lung syndrome) in Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing Shunyi Hospital of Traditional Chinese Medicine, Chinese People's Liberation Army Air Force Characteristic Medical Center, Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University, the Fourth Medical Center of the General Hospital of the People's Liberation Army of China, the Seventh Medical Center of the General Hospital of the People's Liberation Army of China, and the Eighth Medical Center of the General Hospital of the People's Liberation Army of China from April 2023 to June 2023 were randomly divided into control (88 cases) and treatment (90 cases) group. Patients in the control group were po administered with Compound Methoxyphenamine Hydrochloride Capsules, 2 grains/time, three times daily. Patients in the treatment group were po administered with Qingke Pingchuan Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical evaluations were evaluated, the cough severity scores, cough relief and disappearance time, the levels of inflammatory indicators WBC, IL-6 and CRP in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 97.73%, which was significantly higher than that of the control group (89.77%, P < 0.05). After treatment, the cough degree in two groups was significantly improved (P < 0.05), and the improvement of cough score on the 7th day in the treatment group was significantly stronger than that in the control group (P < 0.05). After treatment, the relief time and disappearance time of cough symptoms in the treatment group were significantly shorter than that in the control group (P < 0.05). After treatment, the levels of WBC, IL-6 and CRP in two groups were significantly decreased, and the levels of IL-6 and CRP in the treatment group were significantly improved (P < 0.05). Conclusion Qingke Pingchuan Granules combined with compound methoxyphenamine hydrochloride can significantly improve the clinical effective rate, improve the degree of cough, promote the relief and disappearance of cough symptoms, and reduce the level of inflammation.

R974