目的 探討雙黃連口服液聯(lián)合喜炎平注射液治療小兒皰疹性咽峽炎的臨床效果。方法 選取2022年9月-2023年8月成都市龍泉驛區(qū)婦幼保健院收治的120例皰疹性咽峽炎患兒,采用隨機數(shù)字表法將所有患者分為對照組和治療組,每組各60例。對照組靜脈滴注喜炎平注射液,0.4 mL/kg與生理鹽水混合后靜脈滴注,最大劑量不超過20 mL,1次/d。治療組在對照組治療基礎(chǔ)上口服雙黃連口服液,1歲 ≤ 患兒年齡<3歲,10 mL/次;3歲 ≤ 患兒年齡<7歲,20 mL/次,3次/d。兩組均連續(xù)治療5 d。觀察兩組臨床療效和體溫至正常范圍時間、咽痛消失時間,同時比較兩組治療前后中性粒細(xì)胞與淋巴細(xì)胞比值(NLR)及血清C反應(yīng)蛋白(CRP)、腫瘤壞死因子-α(TNF-α)。結(jié)果 治療后,治療組患兒總有效率是96.67%,顯著高于對照組的86.67%(P<0.05)。治療后,治療組患兒體溫至正常范圍時間、咽痛消失時間均顯著短于對照組(P<0.05)。治療后,兩組患兒的NLR及血清CRP、TNF-α水平較同組治療前顯著降低(P<0.05);治療后,治療組患兒NLR及血清CRP、TNF-α水平低于對照組(P<0.05)。結(jié)論 雙黃連口服液聯(lián)合喜炎平注射液治療小兒皰疹性咽峽炎可獲得較為理想的療效,可迅速改善患兒的體溫異常升高、咽痛等癥狀,對體內(nèi)的炎癥反應(yīng)有明顯的抑制作用,且無明顯不良反應(yīng)。

Objective To explore the efficacy of Shuanghuanglian Oral Liquid combined with Xiyanping Injection in treatment of herpetic angina in children. Methods A total of 120 children with herpetic angina treated in Chengdu Longquanyi District Maternal and Child Health Hospital from September 2022 to August 2023 were selected and divided into control group and treatment group by random number table method, with 60 cases in each group. Patients in the control group were iv administered with Xiyanping Injection, 0.4 mL/kg was mixed with normal saline and then injected intravenously, the maximum dosage was not more than 20 mL, once daily. Patients in the treatment group were po administered with Shuanghuanglian Oral Liquid on the basis of control group, 1 ≤ children age< 3 years old, 10 mL/time; 3 ≤ children nage < 7 years old, 20 mL/time, 3 times daily. Both groups were treated continuously for 5 d. The clinical efficacy, temperature to normal range time, throat pain disappearance time of two groups were observed, and the ratio of neutrophil to lymphocyte (NLR), serum C-reactive protein (CRP), and tumor necrosis faction-α (TNF-α) before and after treatment were compared between the two groups. Results After treatment, the total effective rate of treatment group was 96.67%, which was significantly higher than that of control group (86.67%, P < 0.05). After treatment, the temperature to normal range and the disappearance time of pharyngeal pain in treatment group were significantly shorter than those in control group (P < 0.05). After treatment, the levels of NLR and serum CRP and TNF-α in 2 groups were significantly decreased compared with those before treatment P < 0.05). After treatment, the levels of NLR, serum CRP and TNF-α in treatment group were lower than those in control group (P < 0.05). Conclusion Shuanghuanglian Oral Liquid combined with Xiyanping Injection can obtain ideal curative effect in treatment of herpetic angina in children, and can quickly improve the symptoms of abnormal temperature rise and sore throat in children, and has obvious inhibitory effect on inflammation in the body, which has no obvious adverse reactions

R974

四川省科技計劃項目（2020YFS0275）