目的 評(píng)價(jià)不同產(chǎn)地肺形草的質(zhì)量差異。方法 采用HPLC法測(cè)定肺形草中馬錢苷酸、莫諾苷、獐牙菜苦苷、龍膽苦苷、芒果苷、異葒草苷、異牡荊素、去甲基雛菊葉龍膽酮、當(dāng)藥黃素、3,6,8-三羥基-1-甲基呫噸酮、山楂酸和熊果酸，對(duì)多指標(biāo)成分測(cè)定結(jié)果進(jìn)行主成分分析、正交偏最小二乘法-判別分析，建立加權(quán)優(yōu)劣解距離模型評(píng)估。結(jié)果 16批肺形草明顯聚集為3類；馬錢苷酸、莫諾苷、3,6,8-三羥基-1-甲基呫噸酮、熊果酸、當(dāng)藥黃素和芒果苷是影響肺形草質(zhì)量的主要潛在標(biāo)志物；浙江和江蘇產(chǎn)肺形草整體質(zhì)量較好。結(jié)論 建立的方法控制模式簡(jiǎn)單、評(píng)價(jià)模型科學(xué)合理，可用于肺形草質(zhì)量評(píng)價(jià)。

Objective To evaluate the quality difference of Tripterospermum chinense from different origins. Methods Contents of loganic acid, morroniside, swertiamain, gentiopicrin, mangiferin, isoorientin, isovitexin, demethylbellidifolin, swertisin, 3,6,8-trihydroxy-1-methyl-xanthen-9-one, maslinic acid and ursolic acid in T. chinense were determined by HPLC method. PCA and OPLS-DA were used to analyze the contents of multi-component components, and the weighted-TOPSIS model was established to evaluate the quality. Results 16 Batches of T. chinense were clustered into three categories, and loganic acid, morroniside, 3,6,8-trihydroxy-1-methyl-xanthen-9-one, ursolic acid, swertisin, and mangiferin were the main potential markers affecting the quality of T. chinense. The overall quality of T. chinense from Zhejiang and Jiangsu Provinces is good. Conclusion The established method has a simple control mode and a scientifically reasonable evaluation model, which can be used for the quality evaluation of T. chinense.

R286.02

上海市“醫(yī)苑新星”青年醫(yī)學(xué)人才培養(yǎng)資助計(jì)劃項(xiàng)目（滬衛(wèi)人事[2022]65號(hào)）