目的 探討心脈通膠囊聯(lián)合瑞舒伐他汀鈣片治療老年高脂血癥的臨床療效。方法 選取2021年5月—2023年6月淮南東方醫(yī)院集團總醫(yī)院收治的82例老年高脂血癥患者，將所有患者根據(jù)隨機數(shù)字表法分為對照組和治療組，每組各41例。對照組口服瑞舒伐他汀鈣片，1片/次，1次/d。治療組在對照組基礎上口服心脈通膠囊，4粒/次，3次/d。兩組患者持續(xù)治療12周。比較兩組的治療效果、血脂指標、血液流變學、血清指標。結果 治療后，治療組的總有效率為95.12%，對照組的總有效率為80.49%，組間比較差異顯著（P＜0.05）。治療后，兩組的高密度脂蛋白膽固醇（HDL-C）比治療前大，低密度脂蛋白膽固醇（LDL-C）、三酰甘油（TG）、總膽固醇（TC）比治療前小（P＜0.05）；治療組的HDL-C比對照組大，LDL-C、TG、TC比對照組?。?i>P＜0.05）。治療后，兩組的紅細胞比容（HCT）、纖維蛋白原（FIB）、血漿黏度（PV）均比治療前?。?i>P＜0.05）；治療組的HCT、FIB、PV比對照組小（P＜0.05）。治療后，兩組的血清同型半胱氨酸（Hcy）、血管細胞黏附分子-1（VCAM-1）水平顯著減小，血清脂聯(lián)素（ADPN）水平顯著增大（P＜0.05）；治療組的血清Hcy、VCAM-1水平比對照組小，血清ADPN水平比對照組大（P＜0.05）。結論 心脈通膠囊聯(lián)合瑞舒伐他汀鈣片可提高老年高脂血癥的治療效果，顯著改善血脂水平，改善血液流變學，有助于降低炎癥反應。

Objective To explore the curative effect of Xinmaitong Capsules combined with Rosuvastatin Calcium Tablets in treatment of senile hyperlipidemia. Methods Patients (82 cases) with senile hyperlipidemia in Huainan Oriental Hospital Group General Hospital from May 2021 to June 2023 were divided into control and treatment groups according to the random number table method, and each group had 41 cases. Patients in the control group were po administered with Rosuvastatin Calcium Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Xinmaitong Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 12 weeks. The clinical efficacies, the blood lipid indicators, hemorheology, and serum indicators in two groups were compared. Results After treatment, the total effective rate of the treatment group was 95.12%, while the total effective rate of the control group was 80.49%, with a significant difference between the groups (P < 0.05). After treatment, HDL-C in two groups was higher than before treatment, but LDL-C, TG, and TC in two groups were lower than before treatment (P < 0.05). HDL-C in the treatment group was higher than that in the control group, but LDL-C, TG, and TC in the treatment group were lower than that in the control group (P < 0.05). After treatment, HCT, FIB, and PV in two groups were lower than those before treatment (P < 0.05), and HCT, FIB, and PV in the treatment group were lower than those in the control group (P < 0.05). After treatment, the serum levels of Hcy and VCAM-1 in two groups were significantly decreased, while the serum levels of ADPN in two groups were significantly increased (P < 0.05). The serum levels of Hcy and VCAM-1 in the treatment group were lower than those in the control group, but the serum levels of ADPN were higher than those in the control group (P < 0.05). Conclusion Xinmaitong Capsules combined with Rosuvastatin Calcium Tablets can improve the therapeutic effect of senile hyperlipidemia, significantly improve blood lipid level, improve hemorheology, and help reduce inflammation.

R973

安徽省衛(wèi)生健康委科研項目（AHWJ2021a037）