目的 分析云南白藥膠囊聯(lián)合腎上腺色腙治療肺癌咯血的臨床療效。方法 選取太和縣人民醫(yī)院2021年10月—2023年9月住院的88例肺癌伴咯血患者，利用隨機數(shù)字表法進行分組，對照組和治療組各44例。對照組：腎上腺色腙片，口服，5 mg/次，3次/d。治療組在對照組治療基礎上加用云南白藥膠囊，口服，0.5 g/次，3次/d。兩組療程均為7 d。比較兩組臨床療效、咯血總量和止血時間及治療前后簡式抑郁–焦慮–壓力量表（DASS-21）、36項健康調查簡表（SF-36）評分變化。結果 治療后，治療組總有效率是93.18%，顯著高于對照組的77.27%（P＜0.05）。治療后，治療組咯血總量顯著少于對照組，止血時間較對照組明顯縮短（P＜0.05）。治療后，兩組患者DASS-21中抑郁、焦慮、壓力評分及總評分均顯著降低（P＜0.05）；且DASS-21中各維度評分及總評分均以治療組顯著更低（P＜0.05）。兩組SF-36評分（包括總分及生理、心理健康總分）均于治療后顯著升高（P＜0.05），且SF-36中各領域總分及量表總評分均以治療組顯著更高（P＜0.05）。結論 云南白藥膠囊聯(lián)合腎上腺色腙治療肺癌咯血的總體效果確切，能快速止血，有效減少咯血量，安全性較好，且利于改善患者心理狀態(tài)及生活質量。

Objective To analyze the clinical efficacy of Yunnan Baiyao Capsules combined with carbazochrome in treatment of hemoptysis in lung cancer. Methods A total of 88 patients with lung cancer hemoptysis admitted to Taihe County People's Hospital from October 2021 to September 2023 were selected and divided into control group and treatment group according to random number table method, with 44 cases in each group. Patients in the control group were po administered with Carbazochrome Tablets, 5 mg/time, three times daily. Patients in the treatment group were po administered with Yunnan Baiyao Capsules on the basis of the control group, 0.5 g/time, three times daily. The treatment course of both groups was 7 d. The clinical effect, total amount of hemoptysis and hemostasis time of the two groups were compared, and the changes of the DASS-21 and 36-item health survey summary Form (SF-36) scores before and after treatment were compared. Results After treatment, the total effective rate of treatment group was 93.18%, which was significantly higher than that of control group (77.27%) (P < 0.05). After treatment, the total amount of hemoptysis in treatment group was significantly less than that in control group, and the hemostasis time was significantly shorter than that in control group (P < 0.05). After treatment, the scores of depression, anxiety, stress and the total score of DASS-21 in both groups were significantly decreased (P < 0.05). The score of all dimensions and the total score of DASS-21 were significantly lower in treatment group (P < 0.05). The SF-36 scores (including total score and overall physiological and mental health scores) of both groups were significantly increased after treatment (P < 0.05), and the SF-36 scores in all areas and the total score of the scale were significantly higher than those of treatment group (P < 0.05). Conclusion Yunnan Baiyao Capsules combined with carbazochrome has exact overall effect in treatment of hemoptysis in lung cancer, and can quickly stop bleeding, effectively reduce the amount of hemoptysis with good safety, which is conducive to improving the psychological state and life quality of patients.

R979.1

北京醫(yī)學獎勵基金會睿影基金資助項目（YXJL-2022-0105-0116）