目的 分析復(fù)方氯己定含漱液聯(lián)合阿昔洛韋治療兒童皰疹性口腔炎的臨床療效。方法 選取2021年1月—2023年7月同濟(jì)大學(xué)附屬上海市第四人民醫(yī)院收治的112例皰疹性口腔炎患兒，按隨機(jī)數(shù)字表法將患兒分為對照組和治療組，每組各56例。對照組靜脈滴注注射用阿昔洛韋，15 mg/kg加入5%葡萄糖注射液中稀釋至1 mg/mL后滴注1 h以上，2次/d。治療組患者在對照組治療基礎(chǔ)上給予復(fù)方氯己定含漱液，10 mL/次，含3 min后吐出，2次/d，于早晚刷牙后含漱。兩組療程均為7 d。觀察兩組的臨床療效、臨床表現(xiàn)消失時間，比較治療前后兩組飲食行為問卷（MBQ）、兒童睡眠習(xí)慣問卷中文版（CSHQ）評分、全血淋巴細(xì)胞數(shù)（LYMP#）和血清前白蛋白（PAB）水平變化。結(jié)果 治療后，治療組總有效率是100.00%，顯著高于對照組的89.29%（P＜0.05）。治療后，治療組發(fā)熱、煩躁哭鬧、拒食、疼痛流涎、皰疹及潰瘍的消失時間均顯著短于對照組（P＜0.05）。治療后，兩組MBQ、CSHQ評分均顯著降低（P＜0.05）；治療后，治療組MBQ、CSHQ評分低于對照組（P＜0.05）。治療后，兩組全血LYMP#均顯著降低，而血清PAB水平均顯著上升（P＜0.05）；治療后，治療組全血LYMP#和血清PAB水平改善優(yōu)于對照組（P＜0.05）。結(jié)論 復(fù)方氯己定含漱液聯(lián)合阿昔洛韋治療兒童皰疹性口腔炎具有較佳的安全性及療效，能迅速緩解患兒臨床表現(xiàn)，減輕病毒感染程度，促進(jìn)飲食、睡眠及預(yù)后改善。

Objective To analyze the clinical efficacy of Compound Gargle Solution Chlorhexidine Giuconaie combined with aciclovir in treatment of herpetic stomatitis in children. Methods A total of 112 children with herpetic stomatitis admitted to Shanghai Fourth People’s Hospital Affiliated to Tongji University from January 2021 to July 2023 were selected and divided into control group and treatment group according to random number table method, with 56 cases in each group. Children in control group were iv administered with Aciclovir for injection, 15 mg/kg was added into 5% glucose injection, diluted to 1 mg/mL, and then indribbled for more than 1 h, twice daily. Patients in treatment group were given Compound Gargle Solution Chlorhexidine Giuconaie on the basis of the control group, 10 mL/time, spit out after 3 min, twice daily, and gargle after brushing in the morning and evening. The treatment course of both groups was 7 d. The clinical efficacy and disappearance time of clinical manifestations of two groups were observed, and the scores of Eating Behavior questionnaire (MBQ), Children’s Sleeping Habits Questionnaire (CSHQ), whole blood lymphocyte count (LYmpU #) and serum prealbumin (PAB) were compared between two groups before and after treatment. Results After treatment, the total effective rate in the treatment group was 100.00%, which was significantly higher than 89.29% in control group (P < 0.05). After treatment, the disappearance time of fever, irritability crying, food refusal, sore salivation, herpes and ulcer in the treatment group was significantly shorter than that in control group (P < 0.05). After treatment, MBQ and CSHQ scores were significantly decreased in both groups (P < 0.05). After treatment, MBQ and CSHQ scores in the treatment group were lower than those in the control group (P < 0.05). After treatment, whole blood lympP # was significantly decreased, while serum PAB level was significantly increased in both groups (P < 0.05). After treatment, the whole blood LYmpP # and serum PAB levels in treatment group were better than those in control group (P < 0.05). Conclusion Compound Gargle Solution Chlorhexidine Giuconaie combined with aciclovir has good safety and efficacy in treatment of herpetic stomatitis in children, and can quickly alleviate the clinical manifestations of children, reduce the degree of viral infection, which can promote improvement in diet, sleep, and prognosis.

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