哺乳動物雷帕霉素靶蛋白（mTOR）與癌癥有密切關(guān)系，抑制mTOR通路可以發(fā)揮抗腫瘤作用。目前許多mTOR抑制劑被開發(fā)用于癌癥的治療。一些中藥活性成分如蒽醌類、生物堿類、萜類、多糖類、黃酮類、多酚類成分可以通過抑制mTOR通路誘導(dǎo)腫瘤細(xì)胞凋亡、促進(jìn)自噬、阻斷細(xì)胞周期發(fā)揮抗腫瘤作用。總結(jié)了中藥活性成分抑制mTOR通路抗腫瘤作用的研究進(jìn)展，明確其作用機(jī)制，為臨床應(yīng)用提供參考。

Mammalian target of rapamycin (mTOR) is closely related to cancer, and inhibiting the mTOR pathway can exert anti-tumor effects. At present, many mTOR inhibitors are being developed for the treatment of cancer. Some active ingredients in traditional Chinese medicine, such as anthraquinone, alkaloids, terpenoids, polysaccharides, flavonoids, polyphenols, can exert anti-tumor effects by inhibiting the mTOR pathway through inducing tumor cell apoptosis, promoting autophagy, and blocking the cell cycle. This article summarizes the research progress on anti-tumor effects of active ingredients in traditional Chinese medicine through the mTOR pathway, clarifies their mechanisms of action, and provides reference for clinical applications.

R285；R972

國家自然科學(xué)基金面上項(xiàng)目（81972847）;天津市自然科學(xué)基金多元投入基金資助項(xiàng)目（21JCYBJC01830）;天津市醫(yī)學(xué)重點(diǎn)學(xué)科（專科）建設(shè)項(xiàng)目資助（TJYXZDXK-053B）;天津市人民醫(yī)院院級課題（2022ZLXK01，2022ZLXK07）