心血管疾病已成為威脅人類健康的最主要疾病，其中動(dòng)脈粥樣硬化是心血管疾病的主要原因和病理基礎(chǔ)。大黃素是從大黃、虎杖中獲得的蒽醌衍生物，具有多種藥理作用。大黃素可通過(guò)降低炎癥反應(yīng)、降低氧化應(yīng)激反應(yīng)、調(diào)節(jié)脂質(zhì)代謝、阻止血管平滑肌增殖、保護(hù)血管內(nèi)皮功能、穩(wěn)定動(dòng)脈粥樣硬化斑塊等多種途徑對(duì)動(dòng)脈粥樣硬化發(fā)揮防治作用。綜述了大黃素防治動(dòng)脈粥樣硬化的作用機(jī)制研究進(jìn)展，為大黃素防治動(dòng)脈粥樣硬化的臨床應(yīng)用提供參考。

Cardiovascular disease has become the most important disease threatening human health, and atherosclerosis is the main cause and pathological basis of cardiovascular disease. Emodin is an anthraquinone derivative obtained from Rhei Radix et Rhizoma and Polygoni Cuspidati Rhizoma, which has various pharmacological effects. Emodin can prevent and treat atherosclerosis by reducing inflammatory reaction, reducing oxidative stress reaction, regulating lipid metabolism, preventing vascular smooth muscle proliferation, protecting vascular endothelial function, stabilizing atherosclerotic plaque. This article reviews the research progress of mechanism of emodin in prevention and treatment of atherosclerosis, which provides a reference for the clinical application of emodin in prevention and treatment of atherosclerosis.

R285；R973