骨性關節(jié)炎是以軟骨細胞去分化、軟骨退化和軟骨缺損為特征的致殘性疾病，目前尚缺乏有效的藥物，臨床治療以延緩病情為主。丹參酮ⅡA是丹參中脂溶性成分，具有多種藥理作用，可降低炎癥反應、保護軟骨組織以防治骨性關節(jié)炎。綜述了丹參酮ⅡA防治骨性關節(jié)炎的研究進展，總結其作用機制，為丹參酮Ⅱ_A臨床治療骨性關節(jié)炎提供參考。

Osteoarthritis is a disabling disease characterized by dedifferentiation of chondrocytes, cartilage degeneration, and cartilage defects. At present, there is a lack of effective drugs, and clinical treatment mainly focuses on alleviating symptoms. Tanshinone Ⅱ_A is a lipophilic component from Salviae Miltiorrhizae Radix et Rhizoma, which has multiple pharmacological effects. Tanshinone Ⅱ_A can reduce inflammation and protect cartilage tissue to prevent and treat osteoarthritis. This article summarizes the research progress of tanshinone Ⅱ_A in prevention and treatment of osteoarthritis, summarizes its mechanism, and provides reference for the clinical treatment of osteoarthritis with tanshinone Ⅱ_A.

R285；R982

重慶市大足區(qū)科技發(fā)展項目（DZKJ2023JSYJ-KWXM1042）