目的 建立離子色譜法同時(shí)測(cè)定碳酸氫鈉林格注射液中鈉、鉀、鎂、鈣離子。方法Dionex IonPac^TM CS12A色譜柱（250 mm×4 mm），Dionex IonPac^TM CG12A保護(hù)柱（50 mm×4 mm），以12 mmol/L甲烷磺酸為淋洗液，體積流量為1.00 mL/min，進(jìn)樣體積為20 μL，檢測(cè)方式為電導(dǎo)檢測(cè)，柱箱溫度為30 ℃。結(jié)果 鈉、鉀、鎂、鈣離子分別在6～120、6～120、1～20、2.4～48μg/mL與峰面積線(xiàn)性關(guān)系良好（r＞0.999）；平均回收率分別103.82%、99.75%、101.31%、98.92%，RSD值分別為0.91%、1.40%、1.85%、1.65%。結(jié)論 本實(shí)驗(yàn)耗時(shí)少，操作簡(jiǎn)單，大大提高了檢測(cè)效率，為碳酸氫鈉林格注射液中鈉、鉀、鎂、鈣陽(yáng)離子的檢測(cè)提供了一種新的方法。

Objective To establish a method for simultaneous determination of sodium, potassium, magnesium, and calcium ions in Sodium Bicarbonate Ringer’s Injection. Methods Dionex IonPac^TM CS12A (250 mm × 4 mm) column and Dionex IonPac^TMCG12A (50 mm × 4 mm) protective column were used. Methanesulfonic acid solution (12 mmol/L) was used as eluent; the flow rate was 1.00 mL/min, the sample volume was 20 μL, the detection method was conductivity detection, and the column temperature was 30 ℃. Results The linear relationship between the peak area of sodium, potassium, magnesium, and calcium ions was good (r > 0.999) in the concentration range of 6—120 μg/mL, 6—120 μg/mL, 1—20 μg/mL, and 2.4—48 μg/mL, respectively. The average recoveries were 103.82%, 99.75%, 101.31%, and 98.92% with RSD values of 0.91%, 1.40%, 1.85%, and 1.65%, respectively. Conclusion The method takes less time and is simple to operate, which greatly improves the detection efficiency and provides a new method for the detection of sodium, potassium, magnesium, and calcium cations in Sodium Bicarbonate Ringer’s Injection.

R927.1