目的 探討心脈通膠囊聯(lián)合瑞舒伐他汀對高脂血癥的治療效果。方法 選取2021年3月—2023年9月在西安交通大學(xué)第一附屬醫(yī)院榆林醫(yī)院診治的高脂血癥患者84例，隨機分為對照組（42例）和治療組（42例）。對照組口服瑞舒伐他汀鈣片，5 mg/次，1次/d。治療組在對照組基礎(chǔ)上口服心脈通膠囊，4粒/次，3次/d。兩組均治療8周。觀察兩組患者臨床療效，比較治療前后兩組患者總膽固醇、三酰甘油、非高密度脂蛋白膽固醇（non-HDL-C）、低密度脂蛋白膽固醇（LDL-C）、內(nèi)皮素-1、降鈣素基因相關(guān)肽（CGRP）、超敏C反應(yīng)蛋白（hs-CRP）和單核細胞趨化蛋白-1（MCP-1）水平。結(jié)果 治療后，治療組臨床總有效率為95.24%，比對照組的80.95%明顯升高（P＜0.05）。治療后，兩組總膽固醇、三酰甘油、non-HDL-C、LDL-C、內(nèi)皮素-1、hs-CRP和MCP-1水平均明顯降低，而CGRP水平均明顯升高（P＜0.05），且與對照組比較，治療組各項指標(biāo)改善更加明顯（P＜0.05）。結(jié)論 在瑞舒伐他汀的基礎(chǔ)上聯(lián)合心脈通膠囊治療高脂血癥能有效提升降脂效果，可獲得較為滿意的療效，并能發(fā)揮保護血管內(nèi)皮功能的作用，改善患者的微炎癥狀態(tài)。

Objective To explore the therapeutic effect of Xinmaitong Capsules combined with rosuvastatin in treatment of hyperlipidemia. Methods Patients (84 cases) with hyperlipidemia in Yulin Hospital, the First Affiliated Hospital of Xi’an Jiaotong University from March 2021 to September 2023 were randomly divided into control (42 cases) and treatment (42 cases) group. Patients in the control group were po administered with Rosuvastatin Calcium Tablets, 5 mg/time, once daily. Patients in the treatment group were po administered with Xinmaitong Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical evaluations were evaluated, the levels of total cholesterol, triglyceride, non-HDL-C, LDL-C, endothelin-1, CGRP, hs-CRP and MCP-1 in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 95.24%, which was significantly higher than that of the control group (80.95%, P < 0.05). After treatment, the levels of total cholesterol, triglyceride, non-HDL-C, LDL-C, endothelin-1, hs-CRP and MCP-1 were significantly decreased, while the level of CGRP was significantly increased in two groups (P < 0.05). Compared with the control group, the indexes in the treatment group were improved more significantly (P < 0.05). Conclusion The combination of rosuvastatin and Xinmaitong Capsules in treatment of hyperlipidemia can effectively improve the lipid-lowering effect, achieve satisfactory therapeutic effects, and play a role in protecting vascular endothelial function, improving the patient's micro inflammatory state.

R973

陜西省科技計劃項目（2020SF-318）