目的 觀(guān)察小兒消積止咳口服液聯(lián)合吸入用布地奈德混懸液治療兒童肺炎支原體感染后慢性咳嗽的臨床療效。方法 選取2019年1月—2023年8月于黃山首康醫(yī)院進(jìn)行治療的82例肺炎支原體感染后慢性咳嗽患兒，按隨機(jī)數(shù)字表法將所有患兒分為對(duì)照組和治療組，每組均分配41例。對(duì)照組霧化吸入吸入用布地奈德混懸液，2 mL/次，2次/d。治療組在對(duì)照組基礎(chǔ)上口服小兒消積止咳口服液，年齡＜1歲5 mL/次，1歲≤年齡＜3歲10 mL/次，3歲≤年齡＜5歲15 mL/次，年齡＞5歲20 mL/次，3次/d。5 d為1個(gè)療程，兩組治療3個(gè)療程。比較兩組治療療效、癥狀消失時(shí)間、炎癥因子水平。結(jié)果 治療后，對(duì)照組總有效率為75.61%，治療組的總有效率為92.68%，組間比較差異顯著（P＜0.05）。相比于對(duì)照組，治療組咳嗽、肺部啰音消失時(shí)間更短（P＜0.05）。治療后，兩組血清C反應(yīng)蛋白（CRP）、腫瘤壞死因子-α（TNF-α）、白細(xì)胞介素-6（IL-6）水平均顯著下降（P＜0.05），治療組血清CRP、TNF-ɑ、IL-6水平較對(duì)照組更低（P＜0.05）。結(jié)論 小兒消積止咳口服液聯(lián)合吸入用布地奈德混懸液治療兒童肺炎支原體感染后慢性咳嗽療效更佳，可快速緩解咳嗽癥狀，降低炎癥因子水平。

Objective To observe the clinical efficacy of Xiao'er Xiaoji Zhike Oral Liquid combined with Budesonide Suspension for inhalation in treatment of chronic cough after infected with Mycoplasma pneumoniae in children. Methods 82 Children with chronic cough after Mycoplasma pneumoniae infection who were treated in Huangshan Shoukang Hospital from January 2019 to August 2023 were selected. All children were divided into control group (41 cases) and treatment group (41 cases) according to the random number table. Children in the control group were atomized with Budesonide Suspension for inhalation, 2 mL/time, twice daily. Children in the treatment group po administered with Xiao'er Xiaoji Zhike Oral Liquid on the basis of the control group, with a dosage of 5 mL/time under 1 year old, 10 mL/time for those aged 1—3 years old, and 15 mL/time for those aged 3—5 years old, 20 mL/time for those aged above 5 years old, three times daily. One course had 5 d, and all received 3 courses of treatment. Treatment efficacy, symptom disappearance times, and inflammatory cytokine levels between two groups were compared. Results After treatment, the total effective rate of the control group was 75.61%, while that of the treatment group was 92.68%, with a significant difference between the groups (P < 0.05). Compared to the control group, the disappearance times of cough and lung rales in the treatment group was shorter (P < 0.05). After treatment, the serum levels of CRP, TNF-α, and IL-6 in two groups were significantly decreased (P < 0.05), and the inflammatory cytokine levels in the treatment group were lower than those in the control group (P < 0.05). Conclusion Xiao'er Xiaoji Zhike Oral Liquid combined with Budesonide Suspension for inhalation has better effect on chronic cough after Mycoplasma pneumoniae infection in children, can quickly relieve cough symptoms and reduce the level of inflammatory factors.

R985

安徽省重點(diǎn)研究與開(kāi)發(fā)計(jì)劃項(xiàng)目（2022e07020057）