銀屑病是一種慢性自身免疫性皮膚病，其核心是免疫反應失調(diào)和角質(zhì)形成細胞增殖異常。核因子-κB（NF-κB）在銀屑病中是一種關鍵的調(diào)節(jié)信號通路，通過抑制NF-κB信號途徑或下游轉(zhuǎn)錄因子腫瘤壞死因子-α（TNF-α）或白細胞介素-17（IL-17）/白細胞介素-23（IL-23）成為未來銀屑病治療的一個新方向。中藥針對NF-κB信號通路在銀屑病治療中具有療效確切、手段多樣、不良反應小等優(yōu)勢。總結了中藥調(diào)控絲裂原活化蛋白激酶（MAPK）/NF-κB、NF-κB/信號傳導和轉(zhuǎn)錄激活因子3（STAT3）、Toll樣受體4（TLR4）/NF-κB信號通路治療銀屑病的研究進展，以期為中藥治療銀屑病提供更新策略。

Psoriasis is a chronic autoimmune skin disease, characterized by immune dysfunction and abnormal proliferation of keratinocytes at its core. NF-κB is a key regulatory signaling pathway in psoriasis, and inhibiting the NF-κB signaling pathway or downstream transcription factors such as TNF-α or IL-17/IL-23 has become a new direction for future psoriasis treatment. Traditional Chinese medicine targeting the NF-κB signaling pathway has the advantages of definite therapeutic effect, diverse methods, and minimal adverse reactions in treatment of psoriasis. This article summarizes the research progress on traditional Chinese medicine in treatment of psoriasis by regulating MAPK/NF-κB, NF-κB/STAT3, and TLR4/NF-κB signaling pathways, with the aim of providing updated strategies for the treatment of psoriasis with traditional Chinese medicine.

R986

國家自然科學基金資助項目（81973846）