目的 探討復(fù)方銀花解毒顆粒聯(lián)合帕拉米韋氯化鈉注射液治療兒童流行性感冒的臨床效果。方法 選取河北美和婦產(chǎn)醫(yī)院在2022年1月—2023年12月收治的130例流行性感冒患兒，按隨機(jī)數(shù)字表法將所有患兒分為對(duì)照組和治療組，每組各65例。對(duì)照組靜脈滴注帕拉米韋氯化鈉注射液，1次/d，每次10 mg/kg，不高于600 mg，30 min以上單次靜脈滴注，根據(jù)病情連續(xù)給藥，不超過5 d。治療組在對(duì)照組基礎(chǔ)上開水沖服復(fù)方銀花解毒顆粒，1袋/次，3次/d，持續(xù)治療5 d。比較兩組患兒的臨床療效、主要癥狀完全消失時(shí)間、病毒陰轉(zhuǎn)情況、病情狀態(tài)、炎癥指標(biāo)。結(jié)果 治療后，治療組患兒總有效率為93.85%，對(duì)照組總有效率為81.54%，組間比較差異顯著（P＜0.05）。治療后，治療組發(fā)熱、咳嗽、鼻塞完全消失時(shí)間均短于對(duì)照組（P＜0.05）。治療后，治療組患兒病毒陰轉(zhuǎn)率比對(duì)照組高，差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。治療后，兩組患兒的癥狀評(píng)分、功能評(píng)分、對(duì)父母影響評(píng)分均顯著降低（P＜0.05）；治療組患兒各加拿大急性呼吸道疾病和流感量表（CARIFS）評(píng)分均低于對(duì)照組（P＜0.05）。治療后，兩組患兒的血清淀粉樣蛋白/C反應(yīng)蛋白（SAA/CRP）、白細(xì)胞介素-10（IL-10）、中性粒細(xì)胞/淋巴細(xì)胞的比值（NLR）均低于治療前（P＜0.05）；治療組患兒SAA/CRP、IL-10、NLR均低于對(duì)照組（P＜0.05）。結(jié)論 復(fù)方銀花解毒顆粒聯(lián)合帕拉米韋氯化鈉注射液可提高兒童流行性感冒的療效，改善臨床癥狀，促進(jìn)病毒陰轉(zhuǎn)和病情發(fā)展，降低炎癥反應(yīng)。

Objective To investigate the effect of Compound Yinhua Jiedu Granules combined with Peramivir and Sodium Chloride Injection in treatment of influenza in children. Methods 130 Children with influenza admitted to Hebei Meihe Maternity and Gynecology Hospital from January 2022 to December 2023 were selected, and all children were divided into control group and treatment group according to random number table method, with 65 cases in each group. Children in the control group were iv Peramivir and Sodium Chloride Injection, once daily, 10 mg/kg each time, no more than 600 mg each time, more than 30 min of single intravenous infusion, continuous administration according to the condition, no more than 5 d. On the basis of the control group, children in the treatment group were po Compound Yinhua Jiedu Granules with boiled water, 1 bag/time, 3 times/day, and continued treatment for 5 d. The clinical efficacy, main symptoms complete disappearance time, virus negative transformation, the state of the disease, and the inflammatory indicators were compared between two groups. Results After treatment, the total effective rate was93.85% in the treatment group, and 81.54% in the control group, with significant difference between groups (P < 0.05). After treatment, the complete disappearance times of fever, cough, and nasal congestion in the treatment group was shorter than that in the control group, and the difference was statistically significant (P < 0.05). After treatment, the virus negative conversion rate in the treatment group was higher than that in the control group, and the difference was statistically significant (P < 0.05). After treatment, the symptom score, functional score, and parental influence score of the two groups were significantly decreased (P < 0.05), and all CARIFS scores in the treatment group were lower than those in the control group (P < 0.05). After treatment, SAA/CRP, IL-10, and NLR of the two groups were significantly decreased (P < 0.05), and SAA/CRP, IL-10, and NLR in the treatment group were lower than those in the control group (P < 0.05). Conclusion Compound Yinhua Jiedu Granule combined with Peramivir and Sodium Chloride Injection can improve the curative effect of influenza in children, improve clinical symptoms, promote virus negative transformation and disease development, and reduce inflammation.

R974；R985

河北省醫(yī)學(xué)科學(xué)研究課題計(jì)劃（20220307）