肺纖維化是呼吸系統(tǒng)疾病中常見的慢性、間質(zhì)性肺疾病。目前治療肺纖維化以肺移植治療、抗肺纖維化藥物治療為主。萜類化合物具有顯著的改善肺纖維化的作用，其作用機制分別為調(diào)控轉(zhuǎn)化生長因子-β/Smad、核因子-κB、核因子E2相關(guān)因子2、信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子6、蛋白激酶B信號通路。歸納了萜類化合物調(diào)控信號通路改善肺纖維化的研究進展，以期臨床對肺纖維化治療提供有效的藥物治療思路。

Pulmonary fibrosis is a common chronic and interstitial lung disease in respiratory system diseases. At present, the main treatments for pulmonary fibrosis are lung transplantation and drug therapy. Terpenoids have significant effect on improving pulmonary fibrosis, and their mechanisms of action are to regulate transforming growth factor-β/Smad (TGF-β/Smad), nuclear factor -κB (NF-κB), nuclear factor E2 related factor 2 (Nrf2), signal transduction and transcriptional activation factor 6 (STAT6), and protein kinase B (Akt) signaling pathway. This article summarizes the research progress on terpenoids regulating signaling pathways to improve pulmonary fibrosis, in order to provide effective drug treatment ideas for the clinical treatment of pulmonary fibrosis.

R285

黑龍江省自然科學(xué)基金項目（LH2020H100）；黑龍江省中醫(yī)局中醫(yī)藥科研課題（ZHY2022-182）；哈爾濱市科技創(chuàng)新人才研究專項資金（2017RAQXJ189）