抗癌肽是含有5～50個氨基酸的小型陽離子肽。抗癌肽具有獨特的抗癌機制，如破壞細胞膜、誘導細胞凋亡、抑制血管生成、免疫調節(jié)、誘導DNA損傷和抑制細胞增殖?？拱╇脑谥委煱┌Y方面具有巨大的潛力，但在臨床上應用尚未成熟，仍處于臨床試驗階段。總結了抗癌肽的抗腫瘤作用機制、臨床應用情況，以期為抗癌肽開發(fā)為新型高效低毒的抗癌藥物提供思路。

Anticancer peptides are small cationic peptides containing 5 to 50 amino acids. Anticancer peptides have unique anticancer mechanisms, such as destroying cell membranes, inducing apoptosis, inhibiting angiogenesis, immune regulation, inducing DNA damage, and inhibiting cell proliferation. Anticancer peptides have great potential in treatment of cancer, but their clinical application is not yet mature and is still in the clinical trial stage. This article summarizes the anti-tumor mechanism and clinical application of anticancer peptides, in order to provide ideas for the development of anticancer peptides as new highly efficient and low toxicity anticancer drugs.

R966

廣東省促進經濟高質量發(fā)展（海洋經濟發(fā)展）海洋六大產業(yè)專項基金（GDNRC[2022]38）