目的 探討烏靈膠囊聯(lián)合鹽酸米那普侖片治療焦慮癥的臨床療效。方法 選擇2021年4月—2024年3月石家莊市第八醫(yī)院就診的111例焦慮癥患者，按隨機數(shù)字表法將患者分為對照組（56例）和治療組（55例）。對照組口服鹽酸米那普侖片，初始劑量1片/次，持續(xù)1周后調(diào)整為維持劑量2片/次，2次/d；治療組患者在對照組基礎(chǔ)上口服烏靈膠囊，3粒/次，3次/d。兩組患者連續(xù)治療2個月。比較兩組患者的臨床療效、主觀焦慮程度和血清指標(biāo)水平。結(jié)果 治療組的總有效率為94.55%，高于對照組的總有效率82.14%，組間比較差異顯著（P＜0.05）。治療后，兩組的焦慮自評量表（SAS）、漢密爾頓焦慮量表（HAMA）評分均顯著降低（P＜0.05），且治療組的SAS、HAMA評分比對照組更低（P＜0.05）。治療后，兩組的血清神經(jīng)肽Y（NPY）水平顯著升高，血清多巴胺（DA）、5-羥色胺（5-HT）水平顯著降低（P＜0.05）；治療組的血清NPY水平比對照組高，血清DA、5-HT水平比對照組低（P＜0.05）。結(jié)論 烏靈膠囊聯(lián)合鹽酸米那普侖片可提高焦慮癥的臨床療效，減輕焦慮程度，可能與調(diào)節(jié)神經(jīng)遞質(zhì)分泌有關(guān)。

Objective To explore the clinical efficacy of Wuling Capsules combined with Milnacipran Hydrochloride Tablets in treatment of anxiety disorders. Methods 111 Patients with anxiety disorder in Shijiazhuang Eighth Hospital from April 2021 to March 2024 were divided into control group (56 cases) and treatment group (55 cases) according to random number table method. Patients of the control group were po administered with Milnacipran Hydrochloride Tablets, the initial dose was 1 tablet/time, and was adjusted to the maintenance dose after 1 week, 2 tablets/time, 2 times daily. Patients of the treatment group were given Wuling Capsules on the basis of the control group, 3 capsules/time, 3 times daily. Patients in two groups were treated for 2 months. The clinical efficacy, subjective anxiety degree and serum index level of two groups were compared. Results The total effective rate of the treatment group (94.55%) was higher than 82.14% of the control group, and the difference between the groups was significant (P < 0.05). After treatment, SAS scores and HAMA scores of both groups were significantly decreased (P < 0.05), and SAS scores and HAMA scores of the treatment group were lower than those of the control group (P < 0.05). After treatment, NPY was significantly increased, but DA and 5-HT were significantly decreased in both groups (P < 0.05). NPY in the treatment group was higher than that in the control group, but DA and 5-HT in the treatment group were lower than those in the control group (P < 0.05). Conclusion Wuling Capsules combined with Milnacipran Hydrochloride Tablets can improve the therapeutic effect of anxiety disorders, reduce anxiety levels, and may be related to the regulation of neurotransmitter secretion.

R971

河北省醫(yī)學(xué)科學(xué)研究項目(20230411)