目的 觀察銀丹心泰滴丸聯(lián)合尼可地爾治療微血管性心絞痛的臨床療效。方法 選取2022年4月—2024年4月宜昌市第二人民醫(yī)院收治的126例微血管性心絞痛者，依據(jù)用藥情況隨機(jī)分為對照組（63例）和治療組（63例）。對照組患者口服尼可地爾片，1片/次，3次/d。在對照組的基礎(chǔ)上，治療組口服銀丹心泰滴丸，10丸/次，3次/d。兩組患者用藥28 d。觀察兩組患者臨床療效，比較治療前后兩組患者癥狀緩解時(shí)間，心功能的舒張末期血流速度（EDV）、收縮期最大流速（PSV）、阻力指數(shù)（RI）、搏動(dòng)指數(shù)（PI）指標(biāo)、白細(xì)胞介素-6（IL-6）、內(nèi)皮素-1（ET-1）、內(nèi)皮特異分子-1（ESM-1）和超敏C反應(yīng)蛋白（hs-CRP）水平。結(jié)果 治療后，治療組總有效率（98.41%）明顯高于對照組（84.13%，P＜0.05)。治療后，兩組6 min步行試驗(yàn)（6MWT）、西雅圖心絞痛評分（SAQ）比治療前明顯升高（P＜0.05），且治療組6MWT、SAQ評分均明顯高于對照組（P＜0.05）。治療后，兩組患者EDV、PSV、PI比治療前明顯升高，而RI、ET-1、IL-6、ESM-1、hs-CRP比治療前明顯降低（P＜0.05），且治療組血流動(dòng)力學(xué)和炎性因子指標(biāo)水平明顯好于對照組（P＜0.05）。結(jié)論 銀丹心泰滴丸與尼可地爾協(xié)同治療能較好地改善微血管性心絞痛患者癥狀，調(diào)節(jié)機(jī)體血流變學(xué)狀態(tài)，促進(jìn)心功能增強(qiáng)，減弱炎癥反應(yīng)。

Objective To explore the clinical efficacy of Yindan Xintai Dropping Pills combined with nicorandil in treatment of microvascular angina. Methods Patients (126 cases) with microvascular angina in the Second People’s Hospital of Yichang from April 2022 to April 2024 were divided into control (63 cases) and treatment (63 cases) group according to drug use. Patients in the control group were po administered with Nicorandil Tablets, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Yindan Xintai Dropping Pills, 10 pills/time, three times daily. Patients in two groups were treated for 28 d. After treatment, the clinical evaluations were evaluated, the symptom relief time, and the levels of EDV, PSV, RI, PI, ET-1, IL-6, ESM-1 and hs-CRP in two groups before and after treatment were compared. Results After treatment, the clinical effective rate in the treatment group (98.41%) was significantly higher than that in the control group (84.13%, P < 0.05). After treatment, the 6MWT and SAQ in two groups were significantly higher than those before treatment (P < 0.05), and which in the treatment group were significantly higher than those in the control group (P < 0.05). After treatment, EDV, PSV and PI in two groups were significantly higher than before treatment, but RI, ET-1, IL-6, ESM-1 and hs-CRP were significantly lower than before treatment (P < 0.05), and the levels of hemodynamics and inflammatory factor indicators in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion The synergistic treatment of Yindan Xintai Dropping Pills and nicorandil can improve the symptoms of patients with microvascular angina, regulate hemorheological status, promote the enhancement of cardiac function, and weaken inflammatory reactions.

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