目的 探討神曲消食口服液聯(lián)合復方消化酶膠囊治療小兒厭食癥的效果。方法 選取2023年6月—2024年3月在首都醫(yī)科大學附屬北京兒童醫(yī)院就診的94例厭食癥患兒，依照計算機隨機排列法將患兒分為兩組，每組47例。對照組餐前30 min口服復方消化酶膠囊，2粒/次，3次/d。治療組在對照組基礎(chǔ)上口服神曲消食口服液，3歲≤年齡≤5歲，5 mL/次，5歲＜年齡≤13歲，10 mL/次，3次/d。兩組在治療2周后統(tǒng)計治療效果。比較兩組的總有效率、體質(zhì)量、進食和血清因子水平。結(jié)果 與對照組的總有效率80.85%相比，治療組的總有效率95.74%更高，組間比較差異顯著（P＜0.05）。治療后，兩組的體質(zhì)量均增加，進食時間均縮短（P＜0.05）；治療組的體質(zhì)量高于對照組，進食時間短于對照組（P＜0.05）。治療后，兩組的血清瘦素（LEP）水平降低，血清神經(jīng)肽Y（NPY）、β-內(nèi)啡肽（β-EP）水平升高（P＜0.05）；治療組的血清LEP水平比對照組低，血清NPY、β-EP水平比對照組高（P＜0.05）。結(jié)論 神曲消食口服液聯(lián)合復方消化酶膠囊可提高小兒厭食癥的臨床療效，增加體質(zhì)量，縮短進食時間，改善神經(jīng)遞質(zhì)釋放。

Objective To investigate the effect of Shenqu Xiaoshi Oral Liquid combined with Compound Digestive Enzyme Capsules in treatment of children with anorexia. Methods 94 Children with anorexia who received treatment at Beijing Children’s Hospital, Capital Medical University from June 2023 to March 2024 were selected and divided into two groups using computer randomization with 47 cases in each group. Children in control group took Compound Digestive Enzyme Capsules orally 30 min before meals, 2 capsules/time, 3 times daily. Children in the treatment group took Shenqu Xiaoshi Oral Liquid orally on the basis of the control group, 5 mL each time at the age of 3 to 5 years, and 10 mL each time at the age of 5 to 13 years, 3 times daily. Children in both groups were evaluated after 2 weeks of treatment. The total effective rate, body mass, diet, and serum factor levels were compared between two groups. Results Compared with the total effective rate of 80.85% in the control group, the total effective rate of 95.74% in the treatment group was higher, and the difference between groups was significant (P < 0.05). The body mass of the two groups after treatment was higher than those before treatment, but the feeding time was lower than before treatment (P < 0.05). After treatment, the body mass of the treatment group was higher than that of the control group, but the feeding time of the treatment group was lower than that of the control group (P < 0.05). LEP after treatment was lower than that before treatment, but NPY and β-EP in the treatment group were higher than those before treatment (P < 0.05). LEP in the treatment group was lower than that in the control group after treatment, but NPY and β-EP were higher than those in the control group after treatment (P < 0.05). Conclusion Shenqu Xiaoshi Oral Liquid combined with Compound Digestive Enzyme Capsules can provide therapeutic effect for children with anorexia, improve body weight, reduce eating time, and improve neurotransmitter release.

R985;R975

北京市中醫(yī)婦幼名醫(yī)傳承工作室建設(shè)項目(2022-FYGZS-26)