目的 分析復(fù)方木尼孜其顆粒與枸地氯雷他定片聯(lián)合治療濕疹的臨床效果。方法 選取2021年3月—2023年3月在蘇州市第九人民醫(yī)院就診的100例濕疹患者為研究對(duì)象，按隨機(jī)信封法將患者分為對(duì)照組和治療組，各50例。對(duì)照組溫水送服枸地氯雷他定片，1片/次，1次/d。治療組在對(duì)照組基礎(chǔ)上溫水沖泡后送服復(fù)方木尼孜其顆粒，1袋/次，3次/d。兩組連續(xù)服用7 d。比較兩組臨床療效、皮損情況、生活質(zhì)量、免疫功能和炎癥因子。結(jié)果 治療后，治療組患者的總有效率86.00%高于對(duì)照組總有效率68.00%（P＜0.05）。治療后，兩組濕疹面積及嚴(yán)重指數(shù)（EASI）評(píng)分、瘙癢程度評(píng)分均顯著下降（P＜0.05），且治療組EASI評(píng)分、瘙癢程度評(píng)分低于對(duì)照組（P＜0.05）。治療后，兩組皮膚病生活質(zhì)量量表（DLQI）評(píng)分均下降（P＜0.05），且治療組DLQI評(píng)分低于對(duì)照組（P＜0.05）。治療后，兩組患者CD3⁺、CD4⁺水平升高，CD8⁺水平下降（P＜0.05）；且治療組CD3⁺、CD4⁺高于對(duì)照組，CD8⁺水平低于對(duì)照組（P＜0.05）。治療后，兩組血清白細(xì)胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）水平下降，白細(xì)胞介素-10（IL-10）水平升高（P＜0.05）；且治療組血清IL-6、TNF-α水平低于對(duì)照組，IL-10水平高于對(duì)照組（P＜0.05）。結(jié)論 復(fù)方木尼孜其顆粒聯(lián)合枸地氯雷他定片可有效促進(jìn)濕疹患者皮損恢復(fù)，改善生活質(zhì)量，提高免疫功能，降低炎癥反應(yīng)。

Objective To analyze the efficacy of the combination of Compound Muniziqi Granules and Desloratadine Citrate Disodium Tablets in treatment of eczema. Methods A study was conducted on 100 patients with eczema admitted to Suzhou Ninth People's Hospital from March 2021 to March 2023. They were divided into control group and treatment group using a random envelope method, with 50 patients in each group. Patients of the control group were po administered with Desloratadine Citrate Disodium Tablets, 1 tablets/time, once daily. Patients of the treatment group were po administered with Compound Muniziqi Granules on the basis of the control group, 1 bag/time, 3 times daily. Patients in both groups were treated for 7 d. The total effective rate, skin lesions, quality of life, immune function, and inflammatory factors were compared between two groups. Results The total effective rate (86.00%) of the treatment group was higher than 68.00% of the control group (P < 0.05). After treatment, EASI score and pruritus degree score decreased significantly (P <0.05), and EASI score and pruritus degree score in the treatment group were lower than those in the control group (P <0.05). After treatment, the levels of CD3⁺ and CD4⁺ in both groups increased, while the levels of CD8⁺ in both groups decreased (P < 0.05). The levels of CD3⁺ and CD4⁺ in treatment group were higher than those in the control group, but the levels of CD8⁺ in treatment group was lower than that in the control group. After treatment, the serum levels of IL-6 and TNF-α in both groups were decreased, while the serum levels of IL-10 in both groups were increased (P < 0.05). The serum levels of IL-6 and TNF-α in the treatment group were lower than those in the control group, while the serum levels of IL-10 in the treatment group were higher than those in the control group (P < 0.05). Conclusion Compound Munizizi Granules combined with Desloratadine Citrate Disodium Tablets can effectively promote the recovery of skin lesions in eczema patients, improve the quality of life, enhance immune function and reduce inflammation.

R986

江蘇省衛(wèi)生健康委科研項(xiàng)目(H2019050)