目的 探討清宣止咳顆粒聯(lián)合頭孢呋辛鈉治療小兒支氣管肺炎的臨床療效。方法 選取2022年3月—2024年4月在上海市金山區(qū)中西醫(yī)結合醫(yī)院治療的支氣管肺炎患兒92例，按照隨機數(shù)字表法分為對照組（46例）和治療組（46例）。對照組患兒靜脈滴注注射用頭孢呋辛鈉，40 mg/kg加入生理鹽水100 mL，2次/d。在對照組的基礎上，治療組口服清宣止咳顆粒，5歲≤年齡≤6歲，3/4包/次，6歲＜年齡≤10歲，1包/次，3次/d。兩組患兒用藥7 d。觀察兩組患者臨床療效，比較治療前后兩組患者癥狀、體征好轉時間，咳嗽癥狀評分，及白細胞介素-17（IL-17）、C反應蛋白（CRP）、血清淀粉樣蛋白A（SAA）和血清降鈣素原（PCT）水平。結果 治療后，治療組總有效率為97.83%，明顯高于對照組（80.43%，P＜0.05）。治療后，治療組發(fā)熱、咳嗽、氣促、肺部濕啰音好轉時間較對照組明顯縮短（P＜0.05）。治療后，兩組患兒癥狀評分比治療前明顯降低（P＜0.05），且治療后治療組評分均明顯低于對照組（P＜0.05）。治療后，兩組患兒IL-17、SAA、PCT和CRP水平均明顯降低（P＜0.05），且治療后治療組患兒的炎性因子水平均明顯低于對照組（P＜0.05）。結論 清宣止咳顆粒與頭孢呋辛鈉協(xié)同治療，能有效緩解患兒支氣管肺炎癥狀，促使機體炎性反應減弱。

Objective To observe the clinical efficacy of Qingxuan Zhike Granules combined with cefuroxime sodium in treatment of pediatric bronchopneumonia. Methods Children (92 cases) with bronchopneumonia in Shanghai Jinshan TCM-Integrated Hospital from March 2022 to April 2024 were divided into control (46 cases) and treatment (46 cases) group according to random number table method. Children in control group were iv administered with Cefuroxime Sodium for injection, 40 mg/kg added into normal saline100 mL, twice daily. Children in treatment group were po administered with Qingxuan Zhike Granules, 5 years old ≤ age ≤6 years old, 3/4 bag/time, 6 years old < age ≤10 years old, 1 bag/time, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical evaluations were evaluated, the symptom improvement time, the cough symptom scores, and the levels of IL-17, SAA, PCT, and CRP in two groups before and after treatment were compared. Results After treatment, the clinical effective rate in the treatment group was 97.83%, which was significantly higher than that in the control group (80.43%, P < 0.05). After treatment, the improvement time of fever, cough, shortness of breath, and moist rales in treatment group was significantly shorter than that in control group (P < 0.05). After treatment, the symptom scores of children in two groups were significantly lower than those before treatment (P < 0.05), and the scores in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of IL-17, SAA, PCT, and CRP in two groups were significantly reduced (P < 0.05), and the levels of inflammatory factors in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion he synergistic treatment of cefuroxime sodium and Qingxuan Zhike Granules can effectively alleviate the symptoms of bronchopneumonia in children, which can weaken the inflammatory response of the body.

R974;R985

上海市金山區(qū)中西醫(yī)結合醫(yī)院科研課題(2020-1)