目的 觀察小兒咳喘靈泡騰顆粒聯(lián)合注射用頭孢呋辛鈉聯(lián)合治療兒童支氣管肺炎的臨床效果。方法 選擇2021年12月—2023年7月連云港市第二人民醫(yī)院收治的兒童支氣管肺炎122例，按照隨機(jī)數(shù)字表法將患兒分為對照組（61例）和治療組（61例）。對照組患兒靜脈注射注射用頭孢呋辛鈉，每天30～100 mg/kg，用無菌注射用水溶解，搖勻后加入靜脈輸注管內(nèi)滴注，分3～4次給藥。在對照組治療基礎(chǔ)上，治療組患兒開水沖服小兒咳喘靈泡騰顆粒，2 g/次，3～4次/d。兩組患兒均治療7 d。對比兩組臨床療效、臨床癥狀消失時(shí)間、血常規(guī)指標(biāo)和血清炎性因子。結(jié)果 與對照組總有效率（81.97%）相比，治療組總有效率（96.72%）更高（P＜0.05）。與對照組相比，治療組氣促、濕啰音、咳嗽、哮鳴音、發(fā)熱消失時(shí)間縮短（P＜0.05）。治療后，兩組患兒嗜酸性粒細(xì)胞（EoS）、白細(xì)胞（WBC）計(jì)數(shù)均較治療前降低（P＜0.05），且治療組EoS、WBC計(jì)數(shù)低于對照組（P＜0.05）。治療后，兩組血清白細(xì)胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）、降鈣素原（PCT）、C反應(yīng)蛋白（CRP）水平均較治療前下降（P＜0.05），治療組血清IL-6、TNF-α、PCT、CRP水平低于對照組（P＜0.05）。結(jié)論 小兒咳喘靈泡騰顆粒、注射用頭孢呋辛鈉聯(lián)合治療兒童支氣管肺炎可促進(jìn)臨床癥狀恢復(fù)，改善血常規(guī)和炎癥因子水平。

Objective To observe the therapeutic effect of Xiaoer Kechuanling Effervescent Granules combine with Cefuroxime Sodium for injection in treatment of children with bronchial pneumonia. Methods Total of 122 children with bronchial pneumonia who were admitted to the Second People's Hospital of Lianyungang from December 2021 to July 2023 were divided into control group (61 cases) and treatment group (61 cases) according to the random table method. Children in the control group were iv administered with Cefuroxime Sodium for injection at a dose of 30 — 100 mg/kg daily, dissolved in sterile injection water, shaken well, and added to the intravenous infusion tube for drip administration divided into 3 — 4 doses. On the basis of the control group, children in the treatment group were po administered with Xiaoer Kechuanling Effervescent Granules in boiling water, 2 g/time, 3 — 4 times daily. Both groups of patients were treated for 7 d. The clinical efficacy, disappearance time of clinical symptoms, blood routine indicators, and serum inflammatory factors were compare between two groups. Results The total clinical effective rate of the treatment group was 96.72%, which was higher than 81.97% of the control group (P < 0.05). The disappearance times of dyspnea, rales, cough, wheezing, and fever in the treatment group was shorter than that in the control group (P < 0.05). After treatment, EoS count and WBC count in both groups were decreased (P < 0.05), and EoS count and WBC count in the treatment group were lower than those in the control group (P < 0.05). After treatment, the serum levels of IL-6, TNF-α, PCT, and CRP in both groups were decreased (P < 0.05), and the serum levels of IL-6, TNF-α, PCT, and CRP in the treatment group were lower than those in the control group (P < 0.05). Conclusion The combination of Xiaoer Kechuanling Effervescent Granules and Cefuroxime Sodium for injection can promote the recovery of clinical symptoms, improve blood routine and inflammatory factor levels in children with bronchial pneumonia.

R974;R985

江蘇省婦幼保健科研項(xiàng)目(F2022018)