目的 考察小兒熱速清糖漿聯(lián)合頭孢羥氨芐片治療兒童上呼吸道感染的臨床效果。方法 選取2021年1月—2022年8月河南大學第一附屬醫(yī)院入院治療的上呼吸道感染兒童108例。以隨機數(shù)字表法將患兒分為對照組和治療組，每組54例。對照組在飯前1 h或飯后2 h口服頭孢羥氨芐片，20 mg/kg，2次/d；治療組患兒在對照組基礎上口服小兒熱速清糖漿，1歲≤年齡≤3歲患兒5～10 mL/次、3歲＜年齡≤6歲患兒10～15 mL/次，3次/d。兩組患兒連續(xù)治療14 d。比較兩組臨床療效、癥狀改善時間、血清炎癥因子。結果 對比對照組總有效率72.22%，治療組的總有效率85.18%更高（P＜0.05）；治療組患兒發(fā)熱、咳嗽、流涕、咽痛改善時間明顯短于對照組（P＜0.05）。治療后，兩組血清腫瘤壞死因子-α（TNF-α）、白細胞介素-4（IL-4）、超敏C反應蛋白（hs-CRP）水平均顯著降低（P＜0.05），治療組血清TNF-α、IL-4、hs-CRP水平均顯著降低明顯低于對照組（P＜0.05）。結論 小兒熱速清糖漿聯(lián)合頭孢羥氨芐片治療兒童上呼吸道感染可提高臨床療效，縮短病程，可能是通過降低機體炎癥反應實現(xiàn)的。

Objective To investigate the clinical effect of Xiaoer Resuqing Syrup combined with Cefoxalexin Tablets in treatment of upper respiratory tract infection in children.Methods Total of 108 children with upper respiratory tract infection admitted to the First Affiliated Hospital of Henan University from January 2021 to August 2022 were selected, and were divided into control group and treatment group (54 cases in each group) according to random number table method. Children in the control group were po administered with Cefoperazone Tablets 20 mg/kg, twice daily, 1 h before or 2 h after meals. On the basis of the control group, children in the treatment group were po administered with Xiaoer Resuqing Syrup, 5 — 10 mL/time for children at the age of 1 — 3 years and 10 — 15 mL/time for children at the age of 3 — 6 years, 3 times daily. Two groups of children were treated continuously for 14 d. The clinical efficacy, symptom improvement time, and serum inflammatory factors were compared between two groups. Results The total effective rate was 85.18% in the treatment group, and 72.22% in the control group (P < 0.05). The improvement times of fever, cough, runny nose, sore throat in the treatment group were shorter than those in the control group (P < 0.05). After treatment, the serum levels of TNF-α, IL-4, and hs-CRP in both groups were significantly decreased (P < 0.05), and those in the treatment group were lower than those in the control group (P < 0.05). Conclusion The combination of Xiaoer Resuqing Syrup and Cefoxalexin Tablets in treatment of upper respiratory tract infections in children can improve clinical efficacy and shorten the course of the disease, possibly by reducing the body's inflammatory response.

R974;R985