目的 探討異維A酸紅霉素凝膠聯(lián)合硫酸羥氯喹片治療玫瑰痤瘡的臨床療效。方法 選取2021年5月—2024年1月天津市寶坻區(qū)人民醫(yī)院收治的100例玫瑰痤瘡患者，按隨機(jī)數(shù)字表法將患者分為對照組和治療組，每組各50例。對照組口服硫酸羥氯喹片，0.2 g/次，2次/d。治療組在對照組治療基礎(chǔ)上給予異維A酸紅霉素凝膠外用，每次清潔患處皮膚并擦干，取適量本品涂抹全部患處，2次/d。兩組療程均為8周。觀察兩組臨床療效，比較治療前后病情相關(guān)量表[臨床醫(yī)師紅斑評估量表（CEA）、整體潮紅嚴(yán)重程度量表（GFSS）、研究者整體評價(jià)（IGA）評分]評分、玫瑰痤瘡生活質(zhì)量量表（RosaQoL）評分、癥狀自評量表（SCL-90）評分及毛囊蠕形螨感染情況。結(jié)果 治療后，治療組總有效率是96.00%，顯著高于對照組的84.00%（P＜0.05）。治療后，兩組CEA評分、GFSS評分、IGA評分均較同組治療前顯著降低（P＜0.05）；治療后，治療組病情相關(guān)量表評分改善優(yōu)于對照組（P＜0.05）。治療后，兩組患者RosaQoL評分和SCL-90評分均顯著降低（P＜0.05）；治療后，治療組RosaQoL評分和SCL-90評分低于對照組（P＜0.05）。治療后，兩組2 mm×2 mm和5 mm×5 mm視野范圍內(nèi)的受累毛囊數(shù)量和蠕形螨總數(shù)均顯著減少（P＜0.05）；治療后，治療組毛囊蠕形螨感染情況改善優(yōu)于對照組（P＜0.05）。結(jié)論 異維A酸紅霉素凝膠聯(lián)合硫酸羥氯喹片治療玫瑰痤瘡安全性較佳，能有效抑制毛囊蠕形螨感染，減輕紅斑、潮紅等臨床癥狀，并改善患者生活質(zhì)量和心理狀態(tài)，提高病情控制程度，值得臨床推廣應(yīng)用。

Objective To investigate the clinical efficacy of Isotretinoin Erythromycin Gel combined with hydroxychloroquine sulfate in treatment of rosacea. Methods A total of 100 patients with rosacea treated in Tianjin Baodi District People’s Hospital from May 2021 to January 2024 were selected and divided into control group and treatment group according to random number table method, with 50 cases in each group. Patie nts in the control group were po administered with Hydroxychloroquine Sulfate Tablets, 0.2 g/time, twice daily. Patients in the treatment group were given Isotretinoin Erythromycin Gel on the basis of the control group, cleaned and dried the affected area each time, applied appropriate amount of this product to all affected areas, twice daily. The treatment course of both groups was 8 weeks. The clinical efficacy of two groups was observed. The disease correlation scales (CEA, GFSS, IGA), RosaQoL, SCL-90 and infection status of demodex folliculorum in two groups before and after treatment were compared. Results After treatment, the total effective rate of treatment group was 96.00%, which was significantly higher than that of control group (84.00%, P < 0.05). After treatment, CEA score, GFSS score, and IGA score in two groups were significantly lower than before treatment (P < 0.05). After treatment, the improvement of disease related scale scores in treatment group was better than that in control group (P < 0.05). After treatment, RosaQoL score and SCL-90 score were significantly decreased in both groups (P < 0.05). After treatment, the scores of RosaQoL and SCL-90 in treatment group were lower than those in control group (P < 0.05). After treatment, the number of affected hair follicles and the total number of demodex in 2 mm×2 mm and 5 mm×5 mm visual fields were significantly decreased in both groups (P < 0.05). After treatment, the infection of demodex follicularis in treatment group was better than that in control group (P < 0.05). Conclusion Isotretinoin Erythromycin Gel combined with hydroxychloroquine sulfate has good safety in treatment of rosacea, and can effectively inhibit demodex folliculorum infection, reduce erythema, flushing and other clinical symptoms, and improve the quality of life and psychological state of patients, improve the degree of disease control, which is worthy of clinical promotion and application.

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