流感是人類最常見的呼吸道疾病之一，流感病毒基因突變率高、病毒傳播效率高、耐藥性迅速出現(xiàn)，造成臨床抗病毒治療的療效有限。黃芩苷是黃芩中黃酮類化合物，具有多種活性。黃芩苷可通過抑制病毒生長，限制病毒侵入宿主細胞，降低病毒引起的炎癥反應(yīng)，降低病毒引起的肺組織細胞凋亡，糾正病毒引起的肺組織高凝狀態(tài)發(fā)揮抗流感病毒作用?？偨Y(jié)了黃芩苷抗流感病毒的藥理作用及其作用機制研究進展，為流感的藥物治療提供思路。

Influenza is one of the most common respiratory diseases in humans, and influenza virus has a high mutation rate of influenza virus genes, high virus transmission efficiency, and rapid emergence of drug resistance, resulting in limited efficacy of clinical antiviral treatment. Baicalin is a flavonoid compound in Scutellariae Radix, which has various activities. Baicalin can exert anti-influenza virus effects by inhibiting virus growth, limiting virus invasion into host cells, reducing virus-induced inflammatory responses, lowering virus-induced lung tissue cell apoptosis, and correcting virus-induced hypercoagulable state of lung tissue. This article summarizes the pharmacological effects and mechanisms of baicalin against influenza virus, providing ideas for the drug treatment of influenza.

R285;R286.4

吉林省科技發(fā)展計劃項目(YDZJ202301ZYTS057)