便秘型腸易激綜合征是一種以腹痛或腹部不適伴大便排出困難、排便周期延長(zhǎng)為主要癥狀且常伴隨焦慮、抑郁等精神癥狀的胃腸功能紊亂性疾病。促分泌劑可被用來(lái)治療便秘型腸易激綜合征，治療便秘的同時(shí)也能夠緩解腹痛。促分泌劑目前主要包括3類：氯離子通道激活劑、鳥(niǎo)苷酸環(huán)化酶C激活劑、強(qiáng)效小分子鈉/氫交換體3抑制劑。總結(jié)了促分泌劑治療便秘型腸易激綜合征的作用機(jī)制、療效和安全性，以期為臨床應(yīng)用提供參考。

Constipation-predominant irritable bowel syndrome is a disorder of gastrointestinal function, which is characterized by abdominal pain or abdominal discomfort with difficulty defecation, prolonged defecation time interval, and mental symptoms such as anxiety and depression. Secretagogues can be used to treat constipation-predominant irritable bowel syndrome, which can alleviate abdominal pain while treating constipation. There are currently three main types of secretagogues: chloride channel activators, guanylate cyclase C activators, and potent small molecule sodium/hydrogen exchanger 3 inhibitors. This article summarizes the mechanism, efficacy, and safety of secretagogues in treatment of constipation-predominant irritable bowel syndrome, in order to provide reference for clinical application.

R975

四川省中醫(yī)藥管理局科學(xué)技術(shù)研究專項(xiàng)（2018LC020）