阿爾茨海默病是一種不可逆的、與年齡相關(guān)的神經(jīng)退行性疾病，目前仍然是一種無(wú)法治愈的疾病。自噬可以通過(guò)促進(jìn)β-淀粉樣肽清除、降低Tau蛋白磷酸化發(fā)揮神經(jīng)保護(hù)作用。中藥活性成分可以通過(guò)自噬誘導(dǎo)階段、自噬泡延伸階段、自噬體加工階段以及線粒體自噬干預(yù)阿爾茨海默病。探討中藥活性成分通過(guò)調(diào)控自噬干預(yù)阿爾茨海默病的研究進(jìn)展，以期為中藥治療阿爾茨海默病的臨床應(yīng)用提供參考。

Alzheimer’s disease is an irreversible, age-related neurodegenerative disease that is currently still an incurable disease. Autophagy can play neuroprotective role by promoting the clearance of amyloid β and reducing Tau protein phosphorylation. Active ingredients of traditional Chinese medicine can intervene in Alzheimer's disease through autophagy induction stage, autophagosome extension stage, autophagosome processing stage, and mitochondrial autophagy. This article explores the research progress of active ingredients in traditional Chinese medicine intervening in Alzheimer's disease by regulating autophagy, in order to provide reference for the clinical application of traditional Chinese medicine in treatment of Alzheimer's disease.

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