抑郁癥是常見的精神疾病之一，發(fā)病機(jī)制復(fù)雜，目前尚缺乏有效的根治藥物。黃芩苷是一種來自黃芩的天然黃酮類成分，具有多種藥理作用，可通過促進(jìn)神經(jīng)發(fā)生、增強(qiáng)神經(jīng)突觸可塑性、調(diào)節(jié)丘腦–垂體–腎上腺（HPA）軸、減輕神經(jīng)炎癥反應(yīng)、抑制神經(jīng)元細(xì)胞凋亡、改善線粒體功能發(fā)揮抗抑郁作用?？偨Y(jié)了黃芩苷抗抑郁作用的研究進(jìn)展，分析其作用機(jī)制，為黃芩苷的臨床應(yīng)用提供循證支持。

Depression is a common mental disorder with complex pathogenesis, and there is currently a lack of effective cure drugs. Baicalin is a natural flavonoid extracted from Scutellariae Radix, which has various pharmacological effects. Baicalin can exert antidepressant effects by promoting neurogenesis, enhancing synaptic plasticity, regulating the HPA axis, reducing neuroinflammatory responses, inhibiting neuronal cell apoptosis, and improving mitochondrial function. This paper summarized the research progress on the antidepressant effect of baicalin, analyzed its mechanism of action, and provided evidence-based support for the clinical application of baicalin.

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