目的 探討丹黃祛瘀膠囊聯(lián)合鹽酸多西環(huán)素片治療慢性盆腔炎的臨床療效。方法 分析2021年1月—2024年1月在無錫市婦幼保健院接受治療的105例慢性盆腔炎患者病例資料，根據(jù)用藥方案分為對(duì)照組（52例）和治療組（53例）。對(duì)照組口服鹽酸多西環(huán)素片，1片/次，2次/d；治療組在對(duì)照組基礎(chǔ)上口服丹黃祛瘀膠囊，2粒/次，3次/d。兩組均持續(xù)治療2周。比較兩組患者的臨床療效、臨床癥狀消失時(shí)間、血液流變學(xué)和血清炎癥指標(biāo)。結(jié)果 治療組的總有效率為94.34%，對(duì)照組的總有效率為78.85%，組間比較差異顯著（P<0.05）。治療組下腹疼痛、腰骶脹痛、帶下異常消失時(shí)間均短于對(duì)照組（P<0.05）。治療后，兩組血漿黏度（PV）、紅細(xì)胞比容（HCT）、紅細(xì)胞沉降率（ESR）和血清C反應(yīng)蛋白（CRP）、白細(xì)胞介素-1β(IL-1β)、白細(xì)胞介素-8(IL-8)水平均降低（P<0.05），且治療組PV、HCT、ESR和血清CRP、IL-1β、IL-8水平明顯低于對(duì)照組（P<0.05）。結(jié)論 慢性盆腔炎患者在鹽酸多西環(huán)素片治療的基礎(chǔ)上加用丹黃祛瘀膠囊可提高臨床療效，改善血液流變學(xué)，降低血清炎癥指標(biāo)水平。

Objective To investigate the clinical efficacy of Danhuang Quyu Capsules combined with Doxycycline Hydrochloride Tablets in treatment of chronic pelvic inflammatory disease. Methods The case data of 105 patients with chronic pelvic inflammatory disease treated in Wuxi Maternal and Child Health Hospital from January 2021 to January 2024 were analyzed, and were divide into control group（52 cases） and treatment group（53 cases） according to the medication scheme. The control group took oral Doxycycline Hydrochloride Tablets, 1 tablets/time, twice daily. The treatment group took Danhuang Quyu Capsules orally on the basis of the control group, 2 capsules/time, 3 times daily. Both groups were treated for 2 weeks. The clinical efficacy, disappearance time of clinical symptoms, hemorheology, and serum inflammatory indicators were compared between two groups. Results The total effective rate of the treatment group was 94.34%, the total effective rate of the control group was 78.85%, and the difference between the groups was significant（P＜0.05）. The disappearance times of lower abdominal pain, lumbosacral distension pain, and abnormal vaginal discharge in the treatment group were shorter than those in the control group（P＜0.05）. After treatment, PV, HCT, ESR, and serum CRP, IL-1β, and IL-8 levels in both groups were decreased（P＜0.05）, and PV, HCT, ESR, serum CRP, IL-1β, and IL-8 levels in the treatment group were significantly lower than those in the control group（P＜0.05）. Conclusion Danhuang Quyu Capsules combined with Doxycycline Hydrochloride Tablets can improve clinical efficacy in treatment of chronic pelvic inflammatory disease, improve hemorheology, and reduce serum inflammatory index levels.

R984

江蘇省婦幼健康科研項(xiàng)目(F202107)