目的 探討肺力咳合劑聯(lián)合阿奇霉素治療兒童百日咳的臨床療效。方法 選取2024年1月—2024年8月河南科技大學第一附屬醫(yī)院收治的80例百日咳患兒，按隨機數字表法分為對照組和治療組，每組各40例。對照組口服阿奇霉素顆粒，第1天10 mg/kg，第2～5天5 mg/kg，頓服，用藥5 d后停2 d。治療組在此基礎上口服肺力咳合劑，4歲≤年齡≤7歲者，10 mL/次，7歲＜年齡≤12歲者，15 mL/次，均3次/d。兩組療程7 d。觀察兩組的臨床療效，比較兩組痙攣性咳嗽緩解時間、鼻咽部細菌清除率及治療前后咳嗽癥狀評分、兒童睡眠習慣問卷（CSHQ）評分和血常規(guī)指標[白細胞數（WBC）、淋巴細胞比率（LYMPH%）]。結果 治療組總有效率是95.00%，顯著高于對照組的80.00%（P＜0.05）。治療組痙攣性咳嗽緩解時間顯著短于對照組，鼻咽部細菌清除例數和清除率顯著高于對照組（P＜0.05）。治療后，兩組咳嗽癥狀日間評分、夜間評分及總分均顯著減少（P＜0.05）；治療后，治療組咳嗽癥狀評分低于對照組（P＜0.05）。治療后兩組CSHQ評分和WBC、LYMPH%都低于同組治療前（P＜0.05）；治療后，治療組CSHQ評分和WBC、LYMPH%低于對照組（P＜0.05）。結論 針對兒童百日咳采取肺力咳合劑聯(lián)合阿奇霉素治療，患兒耐受性較好，能有效控制感染和減輕咳嗽癥狀，改善患兒睡眠狀況，促進病情改善。

Objective To investigate the clinical efficacy of Feilike Mixture combined with azithromycin in treatment of children with pertussis. Methods A total of 80 children with pertussis treated in The First Affiliated Hospital of Henan University of Science and Technology from January 2024 to August 2024 were randomly divided into control group and treatment group according to random number table method, 40 cases in each group. Patients in control group were po administered with Azithromycin Granules, 10 mg/kg on the first day, 5 mg/kg on the second to fifth day, after 5 d of medication, stopped for 2 d. Patients in treatment group were po administered with Feilike Mixture on basis of control group, 10 mL/ time for those aged 4 years ≤ 7 years old and 15 mL/time for those aged 7 years < 12 years old, 3 times daily. Both groups were treated for 7 d. The clinical efficacy of two groups were observed, and the remission time of spastic cough, nasopharyngeal bacterial clearance rate, cough symptom score, children's sleep habits questionnaire (CSHQ) score and blood routine indexes (WBC, LYMPH%) before and after treatment were compared between two groups. Results The total effective rate of treatment group was 95.00%, which was significantly higher than that of control group (80.00%, P < 0.05). The remission time of spastic cough in treatment group was significantly shorter than that in control group, and the number and clearance rate of nasopharyngeal bacteria were significantly higher than that in control group (P < 0.05). After treatment, daytime scores, nighttime scores and total scores of cough symptoms were significantly decreased in both groups (P < 0.05). After treatment, the cough symptom score of treatment group was lower than that of control group (P < 0.05). After treatment, the CSHQ score, WBC, LYMPH% in both groups were lower than before (P < 0.05). After treatment, CSHQ score, WBC, and LYMPH% in treatment group were lower than those in control group (P < 0.05). Conclusion The combination of Feilike Mixture and azithromycin for pertussis in children can effectively control infection, and can relieve cough symptoms, improve sleep conditions, which can promote improvement of disease.

R974