目的 探討膽舒膠囊聯(lián)合茴三硫治療結(jié)石性膽囊炎的臨床療效。方法 選取2023年5月—2024年5月在天津市泰達(dá)醫(yī)院診斷并進(jìn)行治療的110例結(jié)石性膽囊炎患者作為研究對(duì)象，以隨機(jī)入組方式分成對(duì)照組和治療組，每組各55例患者。對(duì)照組采用茴三硫片口服進(jìn)行治療，25 mg/次，3次/d；治療組患者在此基礎(chǔ)上加用膽舒膠囊口服治療，0.9 g/次，3次/d。兩組結(jié)石性膽囊炎患者給予持續(xù)8周的治療。觀察兩組的臨床療效，比較治療前后膽囊壁厚度、膽囊排空率，中醫(yī)證候積分、VAS評(píng)分、血清細(xì)胞因子水平的變化情況。結(jié)果 治療后，治療后，治療組和對(duì)照組總有效率分別為94.55%、83.64%，兩組總有效率比較存在顯著性差異（P＜0.05）。經(jīng)過(guò)治療，兩組患者膽囊壁厚度均明顯下降，而膽囊排空率均大幅上漲（P＜0.05）；且治療后，治療組膽囊壁厚度低于對(duì)照組，膽囊排空率高于對(duì)照組（P＜0.05）。經(jīng)過(guò)治療，兩組結(jié)石性膽囊炎患者中醫(yī)證候積分和VAS評(píng)分均顯著降低（P＜0.05）；且治療后，治療組中醫(yī)證候積分和VAS評(píng)分均低于對(duì)照組（P＜0.05）。經(jīng)過(guò)治療，兩組患者血清腫瘤壞死因子-α（TNF-α）、白細(xì)胞介素-6（IL-6）、C-反應(yīng)蛋白（CRP）水平均顯著下降（P＜0.05）；且治療后，治療組血清TNF-α、IL-6及CRP水平顯著低于對(duì)照組（P＜0.05）。結(jié)論 膽舒膠囊聯(lián)合茴三硫片治療結(jié)石性膽囊炎療效顯著，不僅能夠有效改善患者中醫(yī)臨床癥狀和膽囊收縮功能，而且還能夠降低膽囊壁厚度，改善血清學(xué)相關(guān)指標(biāo)，值得臨床上借鑒推廣。

Objective To investigate the therapeutic effect of Danshu Capsules combined with anethol trithione in treatment of calculous cholecystitis. Methods A total of 110 patients with calculous cholecystitis diagnosed and treated in Tianjin Teda Hospital from May 2023 to May 2024 were selected as the study objects and randomly divided into control group and treatment group, with 55 patients in each group. Patients in control group were po administered with Anethol Trithione Tablets, 25 mg/time, three times daily. Patients in treatment group were po administered with Danshu Capsules on basis of control group, 0.9 g/time, 3 times daily. Two groups of patients with calculous cholecystitis were treated for 8 weeks. The clinical effects of two groups were observed, and the changes of gallbladder wall thickness, gallbladder emptying rate, TCM syndrome score, VAS score and serum cytokine level before and after treatment were compared. Results After treatment, the total effective rate of the treatment group and the control group was 94.55% and 83.64%, respectively, and there was a significant difference between the two groups (P < 0.05). After treatment, gallbladder wall thickness decreased significantly in both groups, but gallbladder emptier rate increased significantly (P < 0.05). After treatment, the gallbladder wall thickness of treatment group was lower than that of control group, and the gallbladder emptier rate was higher than that of control group (P < 0.05). After treatment, TCM syndrome scores and VAS scores of patients with calculous cholecystitis in both groups were significantly decreased (P < 0.05). After treatment, TCM syndrome scores and VAS scores in treatment group were lower than those in control group (P < 0.05). After treatment, the serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP) in 2 groups were significantly decreased (P < 0.05). After treatment, the serum levels of TNF-α, IL-6 and CRP in treatment group were significantly lower than those in control group (P < 0.05). Conclusion Danshu Capsules combined with anethol trithione has significant curative effect in treatment of calculous cholecystitis, and can not only effectively improve the clinical symptoms of traditional Chinese medicine and gallbladder systolic function of patients, but also reduce the thickness of gallbladder wall and improve serological related indexes, which is worth clinical reference and promotion.

R975