目的 探討卡度尼利單抗致不良反應的特點，為其臨床安全用藥提供參考。方法 檢索中國知網、萬方數據、維普網、PubMed、Web of Science文獻數據庫中卡度尼利單抗致藥品不良反應案例報道，對納入文獻進行統計分析。結果 共納入16篇共計22例患者。男女各11例，年齡在34～81歲；60歲以上發(fā)生不良反應的患者15例（68.18%），其中8例（36.36%）患者存在合并用藥；發(fā)生時間為用藥后1 d～9個月，主要集中在前3個月內；20例（90.91%）患者經停藥及對癥處理后均好轉，5例（22.73%）患者未提及后續(xù)是否繼續(xù)使用卡度尼利單抗。不良反應累及多個器官或系統，以皮膚及附件（36.36%）最多，其次為心血管系統（31.82%）和內分泌系統（18.18%）。結論 卡度尼利單抗致不良反應可發(fā)生在各年齡段，以用藥后3個月內發(fā)生為主，主要累及皮膚及附件、心血管和內分泌系統等。臨床工作者應加強對卡度尼利單抗不良反應發(fā)生情況及臨床特征的認識，確保臨床用藥安全。

Objective To explore the characteristics of adverse drug reaction induced by cadonilimab and provide a reference for clinically safe medication. Methods Case reports of adverse reactions caused by cadonilimab were retrieved from CNKI, Wanfang Data, VIP, PubMed, and Web of Science literature databases and analyzed statistically. Results A total of 22 patients were included in 16 papers. 11 men and 11 women, aged 34 — 81 years old. 15 Patients over 60 years old (68.18%) had adverse reactions, of which 8 patients (36.36%) had drug combination. The occurrence time was from 1 d to 9 months after medication, mainly concentrated in the first 3 months; 20 patients (90.91%) were improved after withdrawal and symptomatic treatment, and 5 patients (22.73%) did not mention whether to continue to use cardonilizumab. Adverse reactions involved multiple organs or systems, most of which were skin and adnexa (36.36%), followed by cardiovascular system (31.82%) and endocrine system (18.18%). Conclusion Adverse drug reaction caused by cadonilimab can occur in all ages, mainly within 3 months after medication and mainly involve the skin tissue, cardiovascular system, and endocrine system, etc. Clinicians should strengthen their understanding of the occurrence and clinical characteristics of adverse reactions of cadonilimab, and ensure clinical drug safety.

R979.1