膿毒癥肺損傷是膿毒癥常見的并發(fā)癥，是導(dǎo)致死亡的主要原因之一，并且治療方法仍然非常有限。大黃素具有多種藥理作用，可通過降低炎癥反應(yīng)，減輕氧化應(yīng)激反應(yīng)，改善肺通透性，降低細(xì)胞凋亡，增強(qiáng)水清除率，促進(jìn)肺自噬多途徑、多靶點(diǎn)減輕膿毒癥肺損傷。綜述了大黃素治療膿毒癥肺損傷的藥理作用，總結(jié)其作用機(jī)制，為大黃素的臨床運(yùn)用提供依據(jù)。

Lung injury in sepsis is a common complication of sepsis and one of the main causes of death. The treatment of lung injury in sepsis is still very limited. Emodin has various pharmacological effects, and can reduce inflammation, reduce oxidative stress, improve lung permeability, reduce cell apoptosis, enhance water clearance, promote lung autophagy, and reduce lung injury caused by sepsis through multiple pathways and multiple targets. This article reviews the pharmacological effects of emodin in treatment of lung injury in sepsis, summarizes the mechanism of its therapeutic effect, and provides a basis for the clinical application of emodin.

R974

蘭州市科技計(jì)劃項(xiàng)目（2021-1-103）