目的 觀察槐杞黃顆粒與丙酸氟替卡松霧化吸入聯(lián)合治療支氣管哮喘患兒的臨床療效。方法 選取2023年1月—2024年6月自貢市婦幼保健院兒科收治的哮喘120例患兒，按照隨機數(shù)字法分為對照組和治療組，每組60例。對照組給予丙酸氟替卡松吸入氣霧劑，2噴/次，2次/d。治療組在對照組的基礎(chǔ)上口服槐杞黃顆粒，1袋/次，2次/d。兩組治療28 d。對比兩組療效情況，比較兩組兒童呼吸困難評分（PRAM）、哮喘控制測試評分（ACT）、白三烯B4（LTB4）、白細胞介素4（IL-4）、腫瘤壞死因子-α（TNF-α）、白細胞介素17（IL-17）、嗜酸性粒細胞趨化因子（Eotaxin）、單核細胞趨化蛋白1（MCP-1）、γ干擾素（IFN-γ）水平。結(jié)果 藥物治療后，治療組總有效率98.33%，高于對照組83.33%（P＜0.05）。治療28 d后，治療組喘息、咳嗽、氣促、胸悶緩解時間均短于對照組（P＜0.05）。治療后，兩組患兒PRAM評分顯著降低，而ACT評分顯著升高（P＜0.05）；治療后，與對照組對比，治療組PRAM評分較低，ACT評分較高（P＜0.05）。治療后，兩組患兒Eotaxin、MCP-1顯著降低，而IFN-γ水平升高（P＜0.05）；治療后，與對照組對比，治療組Eotaxin、MCP-1水平均較低，IFN-γ水平較高（P＜0.05）。治療后，兩組LTB4、IL-4、TNF-α、IL-17水平均較治療前顯著降低（P＜0.05）；治療后，與對照組對比，治療組患者LTB4、IL-4、TNF-α、IL-17水平均較低（P＜0.05）。結(jié)論 槐杞黃顆粒聯(lián)合丙酸氟替卡松霧化吸入治療效果明顯，有助于改善支氣管哮喘患兒的免疫相關(guān)因子及炎性因子，且藥物安全，值得借鑒與應(yīng)用。

Objective To investigate the therapeutic effect of Huaiqihuang Granules combined with fluticasone propionate in treatment of asthma. Methods A total of 120 children with admitted to the pediatric department of Zigong Maternal and Child Health from January 2023 to June 2024 were selected and divided (60 cases) according to random number method. Patients in control were given Fluticasone Propionate Inhalation Aerosol, 2 spray/time, twice daily. Patients in the treatment were given Huaiqihuang Granules on the basis of control, 1 bag/time, twice daily. Both were treated for 28 d. The efficacy of two groups was compared, PRAM score, ACT score, LTB4, IL-4, TNF-α, IL-17, Eotaxin, MCP-1, and IFN-γ were compared between two groups. Results After drug treatment, the total effective rate 98.33%, which was significantly higher (83.33%, P < 0.05). After 28 d of treatment, the remission time of wheezing, cough, shortness of breath and chest tightness in the treatment group was shorter than that in the control group (P < 0.05). After treatment, PRAM score was significantly decreased, but ACT score was significantly increased in both groups (P < 0.05). After treatment, compared with control group, PRAM score was lower and ACT score was higher in treatment group (P < 0.05). After treatment, Eotaxin and MCP-1 were significantly decreased, but IFN-γ levels were increased in both groups (P < 0.05). After treatment, compared with control group, Eotaxin and MCP-1 levels in treatment group were lower, IFN-γ levels were higher (P < 0.05). After treatment, the levels of LTB4, IL-4, TNF-α, and IL-17 in both groups were significantly decreased compared with those before treatment (P < 0.05). After treatment, the levels of LTB4, IL-4, TNF-α, and IL-17 in treatment group were lower than those in control group (P < 0.05). Conclusion Huaiqihuang Granules combined with fluticasone propionate has significant therapeutic effects in treatment of childhood bronchial asthma, and is helpful to improve immune-related factors and inflammatory factors in children with bronchial asthma, and the drug is safe, which is worthy of reference and application.

R974

自貢市衛(wèi)生健康系統(tǒng)科研課題立項項目（2023-31）