帕金森病是全球第2大影響老年人的神經(jīng)退行性病變，發(fā)病機制復(fù)雜，目前尚缺乏根治方式。木犀草素可通過降低炎癥反應(yīng)、減輕氧化應(yīng)激反應(yīng)、降低突變蛋白的神經(jīng)毒性、抑制神經(jīng)細(xì)胞凋亡、保護多巴胺能神經(jīng)元多靶點、多途徑發(fā)揮防治帕金森病的作用。綜述了木犀草素防治帕金森病的藥理作用研究進展，為帕金森病的藥物治療提供參考。

Parkinson's disease is the second largest neurodegenerative disease affecting the elderly worldwide, with a complex pathogenesis and currently lacking a cure. Luteolin can prevent and treat Parkinson's disease by reducing inflammation, alleviating oxidative stress, reducing neurotoxicity of mutant proteins, alleviating neuronal apoptosis, and protecting dopaminergic neurons through multiple targets and pathways. This article reviews the pharmacological research progress of luteolin in prevention and treatment of Parkinson's disease, providing reference for drug therapy of Parkinson's disease.

R286.1

黑龍江省中醫(yī)藥科研項目（ZYW2023-111）；國家中醫(yī)藥管理局全國名老中醫(yī)藥專家傳承工作室建設(shè)項目（國中醫(yī)藥人教涵〔2022〕75號）