目的 探討地奧心血康膠囊聯(lián)合酒石酸美托洛爾片治療無癥狀性心肌缺血的療效。方法 選擇94例石家莊市人民醫(yī)院2023年2月—2024年11月收治無癥狀性心肌缺血患者，按隨機數字表法分為對照組和治療組，每組各47例。對照組患者服用酒石酸美托洛爾片，2次/d，1片/次。治療組在對照組基礎上服用地奧心血康膠囊，3次/d，2粒/次。患者持續(xù)治療8周。對比兩組的治療療效、心動圖監(jiān)測、心功能指標、血清指標。結果 治療組總有效率89.36%，對照組總有效率72.34%，組間差異有統(tǒng)計學意義（P＜0.05）。兩組治療后的ST段壓低的頻次和持續(xù)時間、無癥狀心肌缺血頻次均低于治療前（P＜0.05）；治療組的ST段壓低的頻次和持續(xù)時間、無癥狀心肌缺血頻次低于對照組（P＜0.05）。兩組治療后的左心射血分數（LVEF）、左心室整體長軸應變（GLS）高于治療前，心肌做功指數（PW-Tei）低于治療前（P＜0.05）；治療組治療后的LVEF、GLS高于對照組，PW-Tei低于對照組（P＜0.05）。兩組治療后的血清單核細胞趨化蛋白-1（MCP-1）、脂蛋白相關磷脂酶（Lp-PLA2）、氨基末端B型利鈉肽前體（NT-proBNP）水平均比治療前低（P＜0.05）；治療組治療后的血清MCP-1、Lp-PLA2、NT-proBNP水平比對照組低（P＜0.05）。結論 地奧心血康膠囊聯(lián)合酒石酸美托洛爾片有助于提高無癥狀性心肌缺血的療效，減輕心肌缺血癥狀，改善心功能，減輕心肌損傷。

Objective To investigate the efficacy of Di'ao Xinxuekang Capsules combined with Metoprolol Tartrate Tablets in treatment of asymptomatic myocardial ischemia. Methods 94 Patients with asymptomatic myocardial ischemia admitted to Shijiazhuang People's Hospital from February 2023 to November 2024 were divided into control group and treatment group using a random number table method, with 47 cases in each group. The control group patients took Metoprolol Tartrate Tablets, one tablet per time, twice daily. On the basis of the control group, the treatment group patients took Di'ao Xinxuekang Capsules, 2 capsules each time, 3 times daily. The patient received continuous treatment for 8 weeks. Therapeutic efficacy, cardiac monitoring, cardiac function indicators, and serum indicators between the two groups were compared. Results The total effective rate of the treatment group was 89.36%, while the total effective rate of the control group was 72.34%, and the difference between the groups was statistically significant (P < 0.05). The frequency and duration of ST segment depression and the frequency of asymptomatic myocardial ischemia in both groups after treatment were lower than those before treatment (P < 0.05). The frequency and duration of ST segment depression and the frequency of asymptomatic myocardial ischemia in the treatment group were lower than those in the control group (P < 0.05). The LVEF and GLS of both groups after treatment were higher than before treatment, but the PW-Tei was lower than before treatment (P < 0.05). The LVEF and GLS of the treatment group were higher than those of the control group after treatment, but PW-Tei was lower than that of the control group (P < 0.05). The serum levels of MCP-1, Lp-PLA2, and NT-proBNP in both groups after treatment were lower than those before treatment (P < 0.05), and the serum levels of MCP-1, Lp-PLA2, and NT-proBNP in the treatment group were lower than those in the control group after treatment (P < 0.05). Conclusion The combination of Di'ao Xinxuekang Capsules and Metoprolol Tartrate Tablets can improve the efficacy of asymptomatic myocardial ischemia, alleviate myocardial ischemia symptoms, improve heart function, and alleviate myocardial injury.

R972

河北省衛(wèi)生健康委醫(yī)學科學研究課題計劃（20210198）