目的 探討大黃通便顆粒聯(lián)合烏司他丁注射液治療急性胰腺炎的臨床療效。方法 選取秦皇島市第一醫(yī)院于2023年1月—2024年12月收治的140例急性胰腺炎，將患者按隨機數(shù)字表法分為對照組和治療組，每組70例。對照組滴注烏司他丁注射液，2次/d，1支/次，持續(xù)滴注2 h。治療組在對照組基礎上沖服大黃通便顆粒，1袋/次，3次/d。兩組持續(xù)治療2周。評估兩組患者的治療效果、癥狀改善情況、病情嚴重程度、血清指標。結果 完成治療，對照組的總有效率為80.00%，治療組的總有效率為91.43%，組間比較差異顯著（P＜0.05）。治療組患者的腹痛、腹脹、腸鳴音、嘔吐消失時間和自主排便時間均短于對照組（P＜0.05）。治療后，兩組的急性胰腺炎床邊指數(shù)（BISAP）評分均比同組治療前小（P＜0.05），治療組的BISAP評分較對照組更?。?i>P＜0.05）。治療后，兩組的血清高遷移率族蛋白B1（HMGB1）、血清淀粉樣蛋白A（SAA）、S100鈣結合蛋白A12（S100A12）、CXC趨化因子配體1（CXCL10）水平顯著減?。?i>P＜0.05），治療組的血清HMGB1、SAA、S100A12、CXCL10水平均低于對照組（P＜0.05）。結論 大黃通便顆粒聯(lián)合烏司他丁注射液可提高急性胰腺炎的療效，改善臨床癥狀，控制病情發(fā)展，減輕炎癥反應。

Objective To investigate the clinical efficacy of Dahuang Tongbian Granules combined with Ulastatin Injection in treatment of acute pancreatitis. Methods 140 Cases of acute pancreatitis admitted to First Hospital of Qinhuangdao from January 2023 to December 2024 were selected and randomly divided into control group and treatment group using a random number table method, with 70 cases in each group. The control group received intravenous infusion of Ulastatin Injection, twice daily, with a dose of 1 tube per dose, continuously for 2 h. On the basis of the control group, the treatment group took Dahuang Tongbian Granules orally, 3 times daily with 1 bag each time. Both groups received continuous treatment for 2 weeks. The treatment effect, symptom improvement, severity of illness, and serum indicators of two groups were compared. Results Patients in the control group achieved a total effective rate of 80.00% after treatment, while patients in the treatment group achieved a total effective rate of 91.43%, with a significant difference between the groups (P < 0.05). The disappearance times of abdominal pain, bloating, bowel sounds, and vomiting, and spontaneous defecation time in the treatment group were shorter than those in the control group (P < 0.05). After treatment, the BISAP scores of both groups were lower than those before treatment, and the BISAP scores of the treatment group was lower than those of the control group (P < 0.05). After treatment, the levels of HMGB1, SAA, S100A12, and CXCL10 were significantly reduced in both groups (P < 0.05), and the levels of HMGB1, SAA, S100A12, and CXCL10 levels in the treatment group were all lower than those in the control group (P < 0.05). Conclusion The combination of Dahuang Tongbian Granules and Ulastatin Injection can improves the efficacy of acute pancreatitis, alleviate clinical symptoms, control disease progression, and reduces inflammatory response.

R975

秦皇島市科學技術研究與發(fā)展計劃項目（20210A080）